118289-17-1

Basic information

• Product Name: 2-Bromo-4-pyridinecarboxaldehyde
• Synonyms: 2-BROMO-4-PYRIDINECARBOXALDEHYDE;2-BROMO-4-FORMYLPYRIDINE;2-BROMOPYRIDINE-4-CARBALDEHYDE;2-BROMOPYRIDINE-4-CARBOXALDEHYDE;2-Bromoisonicotinaldehyde;2-bromo-4-pyridinecarboxaldehydecarboxaldehyde;2-Bromopyridine-4-carbaldehyde ,97%;2-Bromo-4-formylpyridine, 2-Bromoisonicotinaldehyde
• CAS NO: 118289-17-1
• Molecular Formula: C₆H₄BrNO
• Molecular Weight: 186.01
• EINECS: -0
• Product Categories: pharmacetical;Pyridine series;Aldehydes;Pyridines;Pyridine;Aldehyde;Building Blocks
• Mol File: 118289-17-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 52-56°C
• Boiling Point: 272.878 °C at 760 mmHg
• Flash Point: 118.832 °C
• Appearance: Pale yellow/Crystalline Powder
• Density: 1.683 g/cm³
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.619
• Storage Temp.: 0-10°C
• Solubility: soluble in Acetone
• PKA: -1.18±0.10(Predicted)
• Sensitive: Air Sensitive
• BRN: 4243166
• CAS DataBase Reference: 2-Bromo-4-pyridinecarboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-pyridinecarboxaldehyde(118289-17-1)
• EPA Substance Registry System: 2-Bromo-4-pyridinecarboxaldehyde(118289-17-1)

Safety Data

• Hazard Codes: Xi,Xn,F
• Statements: 36/37/38-20/21/22-10-22
• Safety Statements: 26-36/37/39-16
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 118289-17-1(Hazardous Substances Data)

Usage

General Description

2-Bromo-4-pyridinecarboxaldehyde is a chemical compound with the molecular formula C6H4BrNO and a molar mass of 188.01 g/mol. It is a yellow to orange solid that is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. 2-Bromo-4-pyridinecarboxaldehyde is often employed as a building block in the production of pyridine derivatives, which have a wide range of applications in the pharmaceutical and agricultural industries. Its chemical properties enable it to participate in various reactions, such as nucleophilic substitution and condensation, making it a versatile and valuable compound for organic synthesis. However, it is important to handle 2-Bromo-4-pyridinecarboxaldehyde with care, as it is a potentially hazardous chemical that should be used and stored according to proper safety protocols.

InChI:InChI=1/C6H4BrNO/c7-6-3-5(4-9)1-2-8-6/h1-4H

Upstream product

• 383426-36-6 2-bromo-pyridine-4-carbaldehyde oxime 
• 58530-53-3 2,4-dibromopyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 66572-56-3 2-bromoisonicotinic acid 
• 4926-28-7 2-Bromo-4-picoline 
• 695-34-1 2-Amino-4-methylpyridine 
• 865449-19-0 2-bromo-4-(dibromomethyl)pyridine 
• 118289-16-0 (2-bromopyridin-4-yl)methanol 

Downstream Products

• 186461-76-7 3,4-dimethoxy-6-(2-bromo-4-pyridyl)(hydroxy)methylbenzaldehyde dimethylacetal 
• 474799-53-6 2-[(2-bromo-pyridin-4-ylmethyl)-amino]-benzoic acid methyl ester 
• 118289-16-0 (2-bromopyridin-4-yl)methanol 
• 1366404-12-7 1-methyl-N-[(2-phenylpyridin-4-yl)methyl]-N-propyl-1H-imidazole-4-carboxamide 
• 1366404-54-7 1-methyl-N-[(2-phenylpyridin-4-yl)methyl]-N-(propan-2-yl)-1H-imidazole-4-carboxamide 
• 1366404-68-3 N-{[2-(3-fluorophenyl)pyridin-4-yl]methyl}-1-methyl-N-(propan-2-yl)-1H-imidazole-4-carboxamide 
• 1419221-56-9 N-(4-(difluoromethyl)pyridin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide 
• 1204295-87-3 2-bromo-4-(difluoromethyl)pyridine 
• 1420997-69-8 C₂₀H₁₉N₅O₃*ClH 
• 1420998-32-8 {5-[2-(2-methoxy-imidazol-1-yl)pyridin-4-yl]oxazol-2-yl}-(5-methoxymethyl-2-methyl-phenyl)amine 

Relevant articles and documents

The expedient access to bromo-pyridine carbaldehyde scaffolds using gem-dibromomethyl intermediates

A simple, efficient, and general two-step synthesis to bromo-pyridine carbaldehyde scaffolds is described. This direct route involves sequential reactions employing the dibromination of bromo-picolines followed by hydrolysis using an aqueous solution of calcium carbonate. Bromo-pyridine carbaldehyde scaffolds 1-7 were obtained in good overall yield. Bromo-dibromomethyl-pyridine intermediates have been isolated and characterized.

Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors

The histone deacetylases (HDACs) are able to regulate gene expression, and histone deacetylase inhibitors (HDACi) emerged as a new class of agents in the treatment of cancer as well as other human disorders such as neurodegenerative diseases. In the prese

AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS

The invention relates to aminotriazole derivatives of formula (I), wherein A, E, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds. The compounds are useful for the prevention or treatment of diseases, which respond to the modulation of the ALX receptor such as inflammatory diseases.