128946-70-3

Upstream product

• 6426-26-2 (S)-cyclohex-2-en-1-ol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 76358-59-3 (S)-tert-butyl(cyclohex-2-en-1-yloxy)diphenylsilane 
• 1247869-72-2 ((1S,2S,6S)-7-oxabicyclo[4.1.0]heptan-2-yloxy)(tert-butyl)diphenylsilane 

Downstream Products

• 351464-36-3 (1S,2S)-trans-3-cyclohexene-1,2-diol 
• 128946-76-9 [(1R,2R,3R)-3-Ethoxycarbonylmethyl-2-hydroxy-6-tetradec-(Z)-ylidene-cyclohexylsulfanyl]-acetic acid ethyl ester 
• 128946-74-7 [(1R,2R,3R)-3-Carboxymethyl-2-hydroxy-6-tetradec-(Z)-ylidene-cyclohexylsulfanyl]-acetic acid 
• 106553-77-9 ethyl (1α,4β)-4-hydroxycyclohex-2-eneacetate 
• 128946-72-5 ethyl (1α,4β)-4-(tert-butyldiphenylsilyloxy)cyclohex-2-eneacetate 

Relevant academic research and scientific papers

Stereocontrolled synthesis of contiguous C(sp3) - C(aryl) bonds by lanthanide(III)-catalyzed domino aryl-claisen [3,3]-sigmatropic rearrangements

A domino [3,3]-sigmatropic aryl-Claisen rearrangement of cyclic and acyclic bisaryloxy-substituted alkenes can be performed in high yield by using Ln(fod)3 catalysis to obtain bisphenolic products incorporating two contiguous aryl - C(sp3) bonds. Stereospecific rearrangement was observed for cyclic substrates. The precursor diaryl ethers were typically synthesized from the corresponding diols by double arylation procedures using either copper catalyzed coupling of aryltrifluoroborate salts or by S NAr reaction.

CONFORMATIONALLY RESTRICTED LEUKOTRIENE ANTAGONISTS. ASYMMETRIC SYNTHESIS OF SOME NOR-LEUKOTRIENE D4 ANALOGS

The enantiomeric pair of conformationally-restricted nor-LTD4 analogs 10 and 11 have been synthesized stereoselectively from (S)-2-cyclohexen-1-ol

Cyclohexanealkanoic acids

The present invention is directed to 2-hydroxy-4-alkylidenecyclohexanealkanoic acids having a mercaptoalkanoic acid substituent at the 3-position. Esters and amides corresponding to the acids referred to above are also encompassed by the present invention