76358-59-3

Upstream product

• 822-67-3 Cyclohex-2-enol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 288-32-4 1H-imidazole 
• 6426-26-2 (S)-cyclohex-2-en-1-ol 

Downstream Products

• 1384870-20-5 C₁₅H₂₀N₂O₃S 
• 1384870-38-5 N'-(cyclohex-2-en-1-yl)acetohydrazide 
• 123077-19-0 N'-(cyclohex-2-en-1-yl)-4-methylbenzenesulfonohydrazide 
• 499105-51-0 N'-(cyclohex-2-en-1-ylidene)acetohydrazide 
• 1384870-39-6 N-acetyl-N'-cyclohexyl-4-methylbenzenesulfonohydrazide 
• 110-83-8 cyclohexene 
• 106553-74-6 ((1R,2S,6R)-7-oxabicyclo[4.1.0]heptan-2-yloxy)(tert-butyl)diphenylsilane 
• 1247869-72-2 ((1S,2S,6S)-7-oxabicyclo[4.1.0]heptan-2-yloxy)(tert-butyl)diphenylsilane 
• 128946-76-9 [(1R,2R,3R)-3-Ethoxycarbonylmethyl-2-hydroxy-6-tetradec-(Z)-ylidene-cyclohexylsulfanyl]-acetic acid ethyl ester 
• 128946-72-5 ethyl (1α,4β)-4-(tert-butyldiphenylsilyloxy)cyclohex-2-eneacetate 
• 128946-74-7 [(1R,2R,3R)-3-Carboxymethyl-2-hydroxy-6-tetradec-(Z)-ylidene-cyclohexylsulfanyl]-acetic acid 
• 128946-70-3 (1S,6S)-6-(tert-butyldiphenylsilyloxy)cyclohex-2-enol 
• 106553-77-9 ethyl (1α,4β)-4-hydroxycyclohex-2-eneacetate 

Relevant academic research and scientific papers

M -C2B10H11HgCl/AgOTf-Catalyzed Reaction for Reductive Deoxygenation

A m -C2B10H11HgCl/AgOTf-catalyzed reaction of allyl silyl ethers with N -Boc- N ′-tosylhydrazine has been developed. Under mild conditions, the resulting allyl hydrazine products were transformed into naked alkenes in good yield. Furthermore, the used m -C2B10H11HgCl could be recovered quantitatively.

Carbon-nitrogen bond formation between allyl silyl ether and hydrazide promoted by mercuric triflate catalyst

An efficient method for carbon-nitrogen bond formation between ally silyl ethers and N,N-acyltosylhydrazine was developed under very mild conditions using 2 mol% of mercuric triflate [Hg(OTf) as a catalyst. This method does not require the use of any ligand system or supplementary additives and is applicable to the preparation of various N-allylhydrazides with good to excellent yields. Georg Thieme Verlag Stuttgart · New York.

Stereocontrolled synthesis of contiguous C(sp3) - C(aryl) bonds by lanthanide(III)-catalyzed domino aryl-claisen [3,3]-sigmatropic rearrangements

A domino [3,3]-sigmatropic aryl-Claisen rearrangement of cyclic and acyclic bisaryloxy-substituted alkenes can be performed in high yield by using Ln(fod)3 catalysis to obtain bisphenolic products incorporating two contiguous aryl - C(sp3) bonds. Stereospecific rearrangement was observed for cyclic substrates. The precursor diaryl ethers were typically synthesized from the corresponding diols by double arylation procedures using either copper catalyzed coupling of aryltrifluoroborate salts or by S NAr reaction.

Synthesis of conformationally locked carbocyclic nucleosides built on a thiabicyclo[3.1.0]hexane system as a pseudosugar surrogate

The synthesis of prototype models of purine and pyrimidine carbanucleosides built on a 6-thiabicyclo[3.1.0]hexane system as pseudosugar moiety has been investigated. These pyrimidine carbanucleosides proved to be very stable compounds, in contrast to the parent epoxy analogs, which experienced epoxide ring-opening due to intramolecular enol base attack. In addition, as the synthesis of a thiirane moiety fused to a five-membered ring is not a trivial synthetic task, validation and optimization of the existing methods for episulfide preparation were required to access the committed synthetic precursor of the title compounds: (±)-(1RS,2RS,5SR)-6-thiabicyclo[3.1.0]hexan-2- ol, compound 28. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

CONFORMATIONALLY RESTRICTED LEUKOTRIENE ANTAGONISTS. ASYMMETRIC SYNTHESIS OF SOME NOR-LEUKOTRIENE D4 ANALOGS

The enantiomeric pair of conformationally-restricted nor-LTD4 analogs 10 and 11 have been synthesized stereoselectively from (S)-2-cyclohexen-1-ol

Cyclohexanealkanoic acids

The present invention is directed to 2-hydroxy-4-alkylidenecyclohexanealkanoic acids having a mercaptoalkanoic acid substituent at the 3-position. Esters and amides corresponding to the acids referred to above are also encompassed by the present invention

Silyl Halides from (Phenylseleno)silanes. Reaction with Oxiranes and Alcohols To Give Hydrolytically Stable Silyl Ethers.

The preparation of (phenylseleno)silanes and their reactions with halogens (Cl2, Br2, I2) to give silyl halides and diphenyl diselenide are described.Highly hindered tert-butyldimethyl and tert-butyl diphenylsilyl halides were easily prepared.The reaction of silyl bromides and iodides with oxiranes followed by diazabicyclononane treatment gave allylic alcohol silyl ethers.Tertiary alcohols reacted rapidly with silyliodides to give hydrolytically stable silyl ethers.Treatment of the silyl ethers with tetra-n-butylammonium fluoride gave the free alcohols withoutrearrangement or isomerization.