128947-42-2

Upstream product

• 99395-88-7 (S)-4-phenyl-2-oxazolidinone 
• 75-36-5 acetyl chloride 
• 20989-17-7 (2S)-2-phenylglycinol 

Downstream Products

• 174485-59-7 (S)-3-(1-oxo-4,4-dimethyl-2-pentenyl)-4-phenyl-2-oxazolidinone 
• 189498-31-5 3-((E)-3-cyclopropylpropenoyl)-4-(S)-phenyl-2-oxazolidinone 
• 463304-74-7 (4S,3'S)-3-[3-hydroxy-3-(2-naphthyl)-3-(1-trityl-1H-imidazol-4-yl)propanoyl]-4-phenyl-1,3-oxazolidin-2-one 
• 1508318-89-5 C₂₂H₂₉NO₄Si 
• 1508318-94-2 C₂₂H₂₉NO₄Si 
• 1508318-92-0 C₁₉H₂₁NO₄ 
• 221044-43-5 (R)-2-[(R)-Cyclopropyl-(3-dibenzylamino-phenyl)-methyl]-1-((S)-2-oxo-4-phenyl-oxazolidin-3-yl)-butane-1,3-dione 
• 174485-61-1 (4S)-3-<(3S)-3-<3-(dibenzylamino)phenyl>-4,4-dimethylpentanoyl>-4-phenyl-1,3-oxazolidin-2-one 
• 221044-41-3 (S)-3-[(S)-3-Cyclopropyl-3-(3-dibenzylamino-phenyl)-propionyl]-4-phenyl-oxazolidin-2-one 
• 174485-60-0 (4S)-3-<(3S)-3-(3-aminophenyl)-4,4-dimethylpentanoyl>-4-phenyl-1,3-oxazolidin-2-one 
• 463304-63-4 (4S,3'S)-3-[3-hydroxy-3-(1H-imidazol-4-yl)-3-(2-naphthyl)propanoyl]-4-phenyl-1,3-oxazolidin-2-one 

Relevant academic research and scientific papers

Live-Cell Protein Modification by Boronate-Assisted Hydroxamic Acid Catalysis

Selective methods for introducing protein post-translational modifications (PTMs) within living cells have proven valuable for interrogating their biological function. In contrast to enzymatic methods, abiotic catalysis should offer access to diverse and new-to-nature PTMs. Herein, we report the boronate-assisted hydroxamic acid (BAHA) catalyst system, which comprises a protein ligand, a hydroxamic acid Lewis base, and a diol moiety. In concert with a boronic acid-bearing acyl donor, our catalyst leverages a local molarity effect to promote acyl transfer to a target lysine residue. Our catalyst system employs micromolar reagent concentrations and affords minimal off-target protein reactivity. Critically, BAHA is resistant to glutathione, a metabolite which has hampered many efforts toward abiotic chemistry within living cells. To showcase this methodology, we installed a variety of acyl groups inE. colidihydrofolate reductase expressed within human cells. Our results further establish the well-known boronic acid-diol complexation as abona fidebio-orthogonal reaction with applications in chemical biology and in-cell catalysis.

PYRANONE COMPOUNDS USEFUL TO TREAT RETROVIRAL INFECTIONS

The present invention relates to compounds of formulae (I) and (II) which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl[b]pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus, wherein R 10 and R 20 taken together are formulae (III) and (IV). STR1