128958-95-2

Basic information

• Product Name: 2-((4-methoxyphenyl)thio)benzonitrile
• Synonyms: 2-((4-methoxyphenyl)thio)benzonitrile
• CAS NO: 128958-95-2
• Molecular Weight: 241.313
• Mol File: 128958-95-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2-((4-methoxyphenyl)thio)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((4-methoxyphenyl)thio)benzonitrile(128958-95-2)
• EPA Substance Registry System: 2-((4-methoxyphenyl)thio)benzonitrile(128958-95-2)

Safety Data

• Hazardous Substances Data: 128958-95-2(Hazardous Substances Data)

Upstream product

• 696-63-9 4-Methoxybenzenethiol 
• 5335-87-5 4,4'-dimethoxyphenyl disulfide 
• 825-60-5 benzimidic acid ethyl ester 
• 5285-90-5 4-thiocyanatoanisole 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 89-98-5 2-chloro-benzaldehyde 
• 79-24-3 Nitroethane 
• 128958-85-0 2-(4-methoxyphenylthio)benzaldehyde 
• 874-05-5 3-aminoindazole 
• 394-47-8 2-fluorobenzonitrile 
• 19488-09-6 sodium 4-methoxyphenylthiolate 
• 4387-36-4 2-iodobenzonitrile 
• 696-62-8 para-iodoanisole 
• 33174-74-2 2,2 dithiobis(benzonitrile) 

Relevant articles and documents

Sequential C-H activation enabled expedient delivery of polyfunctional arenes

Modular construction of polyfunctional arenes from abundant feedstocks stands as an unremitting pursue in synthetic chemistry, accelerating the discovery of drugs and materials. Herein, using the multiple C-H activation strategy with versatile imidate esters, the expedient delivery of molecular libraries of densely functionalized sulfur-containing arenes was achieved, which enabled the concise construction of biologically active molecules, such as Bipenamol.

Facile synthesis of 1,2-thiobenzonitriles: Via Cu-catalyzed denitrogenative radical coupling reaction

A Cu-catalyzed synthesis of 1,2-thiobenzonitriles via oxidative C-N cleavage of 3-aminoindazoles followed by radical coupling with thiols is developed. A diverse array of 1,2-thiobenzonitriles were obtained in good yields with wide substrate scope. Notably, this is the first example of denitrogenative radical coupling with 3-aminoindazoles.

A medicine intermediate diaryl sulfide synthetic method of the compound

The invention relates to a synthetic method for a medical intermediate diaryl sulfide compound. The method comprises: in an organic solvent, in the presence of a catalyst, alkali, a phosphine-containing ligand and an auxiliary, carrying out reaction on a compound shown in the formula (I) and a compound shown in the formula (II) to obtain a compound shown in the formula (III), wherein the formula (III) is shown in the description; R is H, C1-C6 alkyl, C1-C6 alkoxyl or halogen. According to the method provided by the invention, the catalyst, the alkali, the phosphine-containing ligand, the auxiliary and the solvent are properly selected and combined, so that the components play a role of unique synergistic effect each other, and the target product can be obtained with a high yield, thereby providing a brand new method for synthesizing the compounds. The synthetic method has a good application prospect and industrial production potential in the technical field of organic synthesis, particularly the field of medical intermediate synthesis.