1289642-25-6

Basic information

• Product Name: 5-(4-bromophenylsulfonamido)pentyl methanesulfonate
• CAS NO: 1289642-25-6
• Molecular Weight: 400.315
• Mol File: 1289642-25-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(4-bromophenylsulfonamido)pentyl methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-bromophenylsulfonamido)pentyl methanesulfonate(1289642-25-6)
• EPA Substance Registry System: 5-(4-bromophenylsulfonamido)pentyl methanesulfonate(1289642-25-6)

Safety Data

• Hazardous Substances Data: 1289642-25-6(Hazardous Substances Data)

Upstream product

• 98-58-8 4-bromobenzenesulfonyl chloride 
• 2508-29-4 5-hydroxypentylamine 
• 918638-44-5 4-bromophenyl sulfonic acid-(5-hydroxypentyl)-amide 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 1289642-26-7 N-(5-(pyrrolidinyl)pentyl)-4-bromobenzenesulfonamide trifluoroacetate 
• 1289642-18-7 N-(5-(dimethylamino)pentyl)-4-bromobenzenesulfonamide trifluoroacetate 
• 1289642-16-5 N-(5-(methylamino)pentyl)-4-bromobenzenesulfonamide trifluoroacetate 
• 1289642-20-1 C₂F₃O₂^(1-)*C₁₄H₂₄BrN₂O₂S⁽¹⁺⁾ 

Relevant articles and documents

Rational Adaptation of L3MBTL1 Inhibitors to Create Small-Molecule Cbx7 Antagonists

Chromobox homolog 7 (Cbx7) is an epigenetic modulator that is an important driver of multiple cancers. It is a methyl reader protein that operates by recognizing and binding to methylated lysine residues on specific partners. Herein we report our efforts to create low-molecular-weight inhibitors of Cbx7 by making rational structural adaptations to inhibitors of a different methyl reader protein, L3MBTL1, inhibitors that had previously been reported to be inactive against Cbx7. We evaluated each new inhibitor for Cbx7 inhibition by fluorescence polarization assay, and also confirmed the binding of selected inhibitors to Cbx7 by saturation-transfer difference NMR spectroscopy. This work identified multiple small-molecule inhibitors with modest (IC50: 257–500 μm) potency.