1289646-90-7

Upstream product

• 1129633-50-6 (E)-ethyl 2-ethynyl-3-(furan-2-yl)acrylate 
• 126200-19-9 ethyl 4-formyl-3-hydroxybenzoate 
• 1034-49-7 (bromomethyl)triphenyl phosphonium bromide 
• 1289646-88-3 ethyl 2-(1,3-dioxolan-2-yl)methyl-3-(furan-2-yl)acrylate 

Downstream Products

• 77095-51-3 benzofuran-6-carboxylic acid 
• 1194550-67-8 ((S)-benzyl 2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-methylsulfonyl)phenyl)propanoate 
• 1025967-78-5 (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid 

Relevant academic research and scientific papers

Preparation method of benzofuran derivative

The invention discloses a preparation method for synthesizing a benzofuran derivative. The specific implementation method is as shown in the specification. The method has novel synthetic route, simpleand convenient operation, high yield, and good safety, and is suitable for industrial production. A novel synthetic method of an intermediate VI is also designed, a Wittig reaction is carried out, and then ring-closing is carried out to obtain a benzofuran ring.

LFA-1 INHIBITOR AND POLYMORPH THEREOF

Methods of preparation and purification of a compound, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA -1 mediated diseases are also disclosed.

Synthesis of naphthalenes via platinum-catalyzed hydroarylation of aryl enynes?

An efficient synthetic method of functionalized naphthalenes having hydrogen, alkyl, alkenyl, aryl, or heteroaryl groups on the 4-position and ethoxycarbonyl group on the 2-position was developed through selective Pt-catalyzed 6-endo intramolecular hydroa