128981-12-4

Basic information

• Product Name: O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> H-phiosphonodithioate
• CAS NO: 128981-12-4
• Molecular Weight: 640.718
• Mol File: 128981-12-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> H-phiosphonodithioate(CAS DataBase Reference)
• NIST Chemistry Reference: O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> H-phiosphonodithioate(128981-12-4)
• EPA Substance Registry System: O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> H-phiosphonodithioate(128981-12-4)

Safety Data

• Hazardous Substances Data: 128981-12-4(Hazardous Substances Data)

Upstream product

• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 128981-11-3 C₃₅H₃₅N₈O₇P 

Downstream Products

• 127088-91-9 triethylammonium O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) phosphorodithioate 
• 118149-24-9 O-<5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl> O-(3'-O-acetylthymidin-5'-yl) hydrogenphosphonothioate 
• 169836-72-0 O-(5'-O-(4,4'-dimethoxytrityl)thymidine-3'-yl) O-(9-fluorenemethyl) phosphorodithioate 

Relevant articles and documents

Oxidative formation of phosphorodithioates via H-phosphonodithioates

H-Phosphonodithioate esters can be linked to a second alcohol via an oxidative coupling procedure to generate a phosphorodithioate diester. Nucleoside-cholesterol and nucleoside-amino acid phosphorodithioates were synthesized via this route.

Synthesis of oligonucleotide phosphorodithioates

The synthesis of DNA containing sulfur at the two nonbonding internucleotide valencies is reported. Several different routes using either tervalent or pentavalent mononucleotide synthons are described.