128982-09-2Relevant academic research and scientific papers
A practical preparation of methyl 4-(trimethylsilyl)benzoate: An intermediate in the synthesis of SDZ 63135
Amedio Jr.,Lee,Prasad,Repic
, p. 2599 - 2612 (1995)
An improved synthesis of ester 1 is described utilizing a bromine-lithium exchange and a Grignard-mediated methoxycarbonylation reaction starting from 1,4-dibromobenzene. Compound 1 was converted to 2 through a condensation and dehydration sequence with an overall yield of 41.5%.
Antitumor Activity of 5-Aryl-2,3-dihydroimidazoisoquinolines
Houlihan, William J.,Munder, Paul G.,Handley, Dean A.,Cheon, Seung H.,Parrino, Vincent A.
, p. 234 - 240 (2007/10/02)
A series of 5-aryl-2,3-dihydroimidazoisoquinolines previously reported to be platelet activating factor (PAF) receptor antagonist were evaluated for potential antitumor activity.Several compounds, such as the 5-(4'-tert-butylphenyl) (65), 5- (69), and 5-(4'-cyclohexylphenyl) (71) analogs showed very good cytotoxicity against several tumor cell lines. 5--2,3-dihydroimidazoisoquinoline (SDZ 62-434, 53) was more effective on a milligram per kilogram basis than the clinical cytostatic agent edelfosine (1) in increasing survivors and decreasing tumor volume in the oral mouse Meth A fibrosarcoma assay.It was selected for further development and is currently in phase I clinical trials in cancer patients.
