A practical preparation of methyl 4-(trimethylsilyl)benzoate: An intermediate in the synthesis of SDZ 63135

DOI: 10.1080/00397919508011806

Source and publish data:

Synthetic Communications p. 2599 - 2612 (1995)

Update date:2022-07-29

Topics:

Authors:

Amedio Jr.

Lee Lee

Prasad Prasad

Repic Repic

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Article abstract of DOI:10.1080/00397919508011806

An improved synthesis of ester 1 is described utilizing a bromine-lithium exchange and a Grignard-mediated methoxycarbonylation reaction starting from 1,4-dibromobenzene. Compound 1 was converted to 2 through a condensation and dehydration sequence with an overall yield of 41.5%.

Full text of DOI:10.1080/00397919508011806

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