A practical preparation of methyl 4-(trimethylsilyl)benzoate: An intermediate in the synthesis of SDZ 63135

Article abstract of DOI:10.1080/00397919508011806

An improved synthesis of ester 1 is described utilizing a bromine-lithium exchange and a Grignard-mediated methoxycarbonylation reaction starting from 1,4-dibromobenzene. Compound 1 was converted to 2 through a condensation and dehydration sequence with an overall yield of 41.5%.

Full text of DOI:10.1080/00397919508011806

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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A Practical Preparation of
Methyl 4-(Trimethylsilyl)-
benzoate: An Intermediate in
the Synthesis of SDZ 63135
John C. Amedio Jr a , George T. Lee a , Kapa Prasad a
& Oljan Repic a
a Technical R & D, Chemical R & D , Sandoz Research
Institute, Sandoz Pharmaceuticals Corp. East
Hanover , New Jersey, 07936, USA
Published online: 23 Sep 2006.
To cite this article: John C. Amedio Jr , George T. Lee , Kapa Prasad & Oljan Repic
(1995) A Practical Preparation of Methyl 4-(Trimethylsilyl)-benzoate: An Intermediate
in the Synthesis of SDZ 63135, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 25:17, 2599-2612, DOI:
10.1080/00397919508011806
To link to this article: http://dx.doi.org/10.1080/00397919508011806
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