128993-53-3Relevant academic research and scientific papers
Coenzyme-inspired chemistry 1: The C-2 alkylation of 4,5-dihydroimidazoles
Jones, Raymond C.F.,Nichols, John R.
, p. 4114 - 4119 (2013)
Alkylation of 4,5-dihydroimidazoles at C-2 is accomplished using a double umpolung of the reactivity of that position, via sulfenylation of a nucleophilic C-2 lithio-species and substitution using an alkyl nucleophile. Arylation via unexpected sulfide con
Tetrahydrofolate coenzyme models: Imidazolines as nucleophilic C1-transfer reagents
Jones,Nichols
, p. 1767 - 1770 (2007/10/02)
1-Benzyl-2-imidazoline is deprotonated at C-2 and alkylated by a sulphenylation-substitution sequence (to complete a formal C1-transfer), whereas arylation occurs by an unusual sulphenylation-sulphide contraction pathway.
