129011-98-9Relevant articles and documents
Discovery of a potent and highly fluorescent sirtuin inhibitor
Yoon,Ali,Wei,Choon,Shirazi,Parang
, p. 1857 - 1863 (2015/10/20)
In search for potent sirtuin inhibitors, a series of diversified 1,2-disubstituted benzimidazole analogues were synthesized using a one-pot method. The most potent compound in the series (BZD9L1) was discovered to show high autofluorescence which can be utilized to predict its localization in cells. More importantly, BZD9L1 displayed strong antiproliferative effects against a panel of cancer cells tested. Molecular docking studies also help to explain the observed structure-activity relationship.
Convenient Routes to Substituted Benzimidazoles and Imidazolopyridines Using Nitrobenzene as Oxidant
Yadagiri, Bathini,Lown, J. William
, p. 955 - 963 (2007/10/02)
Various substituted benzimidazoles and imidazolopyridines 5a-c have been prepared by condensation of appropriate diamines and aldehydes in nitrobenzene.This method has been utilized to synthesize compounds 5f-h, which are analogues of the DNA binding fluorochrome Hoechst 33258.