129011-98-9

Basic information

• Product Name: 5(6)-CARBETHOXY-2-(4'-HYDROXYPHENYL)-BENZIMIDAZOLE
• Synonyms: 5(6)-CARBETHOXY-2-(4'-HYDROXYPHENYL)-BENZIMIDAZOLE
• CAS NO: 129011-98-9
• Molecular Formula: C₁₆H₁₄N₂O₃
• Molecular Weight: 282.298
• Mol File: 129011-98-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 521.1±56.0 °C(Predicted)
• Appearance: /
• Density: 1.324±0.06 g/cm3(Predicted)
• PKA: 9.19±0.15(Predicted)
• CAS DataBase Reference: 5(6)-CARBETHOXY-2-(4'-HYDROXYPHENYL)-BENZIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5(6)-CARBETHOXY-2-(4'-HYDROXYPHENYL)-BENZIMIDAZOLE(129011-98-9)
• EPA Substance Registry System: 5(6)-CARBETHOXY-2-(4'-HYDROXYPHENYL)-BENZIMIDAZOLE(129011-98-9)

Safety Data

• Hazardous Substances Data: 129011-98-9(Hazardous Substances Data)

Upstream product

• 76918-64-4 ethyl 4-amino-3-nitrobenzoate 
• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 37466-90-3 ethyl 3,4-diaminobenzoate 
• 367-80-6 ethyl 4-fluoro-3-nitrobenzoate 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 129012-16-4 5⁽⁶⁾-hydroxymethyl-2-(4-hydroxyphenyl)benzimidazole 
• 129012-01-7 4-{5-[5-(4-Methyl-piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl]-1H-benzoimidazol-2-yl}-phenol 
• 129012-05-1 2-(4-hydroxyphenyl)benzimidazole 5⁽⁶⁾-carboxaldehyde 

Relevant articles and documents

Discovery of a potent and highly fluorescent sirtuin inhibitor

In search for potent sirtuin inhibitors, a series of diversified 1,2-disubstituted benzimidazole analogues were synthesized using a one-pot method. The most potent compound in the series (BZD9L1) was discovered to show high autofluorescence which can be utilized to predict its localization in cells. More importantly, BZD9L1 displayed strong antiproliferative effects against a panel of cancer cells tested. Molecular docking studies also help to explain the observed structure-activity relationship.

Convenient Routes to Substituted Benzimidazoles and Imidazolopyridines Using Nitrobenzene as Oxidant

Various substituted benzimidazoles and imidazolopyridines 5a-c have been prepared by condensation of appropriate diamines and aldehydes in nitrobenzene.This method has been utilized to synthesize compounds 5f-h, which are analogues of the DNA binding fluorochrome Hoechst 33258.