37466-90-3

Usage

InChI:InChI=1/C9H12N2O2/c1-2-13-9(12)6-3-4-7(10)8(11)5-6/h3-5H,2,10-11H2,1H3

Upstream product

• 76918-64-4 ethyl 4-amino-3-nitrobenzoate 
• 64-17-5 ethanol 
• 619-05-6 3,4-diaminobenzoic acid 
• 84228-43-3 2-nitro-5-ethoxycarbonylaniline 
• 7664-93-9 sulfuric acid 
• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 367-80-6 ethyl 4-fluoro-3-nitrobenzoate 
• 1588-83-6 4-amino-3-nitrobenzoic acid 

Downstream Products

• 717-37-3 ethyl 2-methyl-1H-benzimidazole-5-carboxylate 
• 53454-26-5 2-(4-chloro-3-methyl-phenoxy)-2-oxo-2,3-dihydro-1H-2λ⁵-benzo[1,3,2]diazaphosphole-5-carboxylic acid ethyl ester 
• 63053-16-7 2-pyridin-2-yl-1⁽³⁾H-benzoimidazole-5-carboxylic acid ethyl ester 
• 129011-98-9 ethyl 2-(4-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate 
• 126824-19-9 ethyl 2-(4-methoxyphenyl)-1H-benzo[d]imidazole-5-carboxylate 
• 134767-67-2 4-Amino-3-[2-(4-chloro-phenyl)-acetylamino]-benzoic acid ethyl ester 
• 134767-66-1 4-Amino-3-[2-(2-chloro-phenyl)-acetylamino]-benzoic acid ethyl ester 
• 134767-72-9 2-(phenoxymethyl)-1H-benzo[d]imidazole-5-carboxylic acid 
• 134767-68-3 4-Amino-3-[2-(4-methoxy-phenyl)-acetylamino]-benzoic acid ethyl ester 
• 134767-69-4 4-Amino-3-[2-(4-nitro-phenyl)-acetylamino]-benzoic acid ethyl ester 
• 291506-95-1 4-amino-3-(2,2,2-trifluoro-acetylamino)-benzoic acid ethyl ester 
• 126824-19-9 2-(4-methoxy-phenyl)-1H-benzimidazole-6-carboxylic acid ethyl ester 
• 92807-00-6 ethyl 2-mercaptobenzimidazole-5-carboxylate 
• 870114-99-1 2-(3,4-dichloro-phenyl)-1H-benzoimidazole-5-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis and properties of alkyl chain substituted naphthalenetetracarboxylic monoanhydride monoimides and unsymmetrically substituted naphthalene derivatives

1,4,5,8-Naphthalenedianhydride is converted to N-(2-ethylhexyl)-1,4,5,8-naphthalenetetracarboxylic monoanhydride monoimide (2a) and N-(2-hydroxyethyl)-1,4,5,8-naphthalenetetracarboxylic monoanhydride monoimide (2c) through the potassium salt prepared from

The First Synthesis of Protected 5-Hydroxymethyl-2-cyanomethylbenzimidazole

Protected 5-hydroxymethyl-2-cyanomethylbenzimidazole 4 has successfully been synthesized starting from 3,4-diaminobenzoic acid 1. The benzimidazole 4 is expected to be a useful intermediate for the synthesis of new functional molecules such as drugs, agro

Amide and ester derivatives of chlorido[4-carboxy-1,2-disalicylideneaminobenzene]iron(iii) as necroptosis and ferroptosis inducers

In continuation of the structure-activity study about 4-substituted chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(iii) complexes as necroptosis and ferroptosis inducers, we introduced a 4-COOH group at the 1,2-phenylenediamine moiety of the lead

Synthesis and Crystal Structures of Ethyl 2-(4-Methoxyphenyl)-1H-benzo[d]imidazole-5-carboxylate Dihydrate and Its Building Block 4-Fluoro-3-nitrobenzoic Acid

The title compound, ethyl 2-(4-methoxyphenyl)-1H-benzo[d]imidazole-5-carboxylate dihydrate (5), was synthesized and its crystal structure was studied by single-crystal X-ray diffraction technique. Compound 5 is crystallized in the centrosymmetric triclinic space group P1 ˉ with Z = 4 and Z′ = 2, and unit-cell parameters of a = 8.9190 (3) ?, b = 12.6888 (4) ?, c = 14.7111 (5) ?, α = 98.4855 (10)°, β = 101.6379 (9)°, γ = 95.4346 (10)° and V = 1599.43 (9) ?3. Its starting material, 4-fluoro-3-nitrobenzoic acid (1), is crystallized in the non-centrosymmetric monoclinic space group P21 and Z = 4 with unit-cell parameters of a = 3.7170 (4) ?, b = 12.6475 (13) ?, c = 15.5237 (15) ?, α = 90°, β = 91.9786 (16)°, γ = 90° and V = 729.35 (13) ?3. It was noted that strong hydrogen bonds play important roles in the crystal packing of both compounds, especially in 5, in which the co-crystallized water molecules act as both strong hydrogen bond donor and strong hydrogen bond acceptor. Graphical Abstract: Two molecule of compound 5 crystallized in a non symmetrical manner with four co-crystallized water molecules which play an important role in the crystal packing as strong hydrogen-bond donors. [Figure not available: see fulltext.].

BENZOIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS

The invention relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing said compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading t

ANTI-ANGIOGENIC AGENTS AND USES THEREOF

There is herein disclosed a compound of formula I: or a salt solvate or pharmaceutically acceptable derivative thereof, wherein R1 to R7 is as defined herein for use in the treatment of angenogenis and related conditions.

COMPOUND AND METHOD FOR INHIBITING SIRTUIN ACTIVITIES

A compound of formula wherein R1 is selected from the group consisting of hydrogen, halogen, hydroxyl, carboxyl, alkyl of up to 5 carbon atoms, imidazolyl, piperazinyl, morpholinyl, benzyl, R4OH or R4COOH, where R4 is (CH2)m and m is an integer of from 1 to 4; R2 is selected from the group consisting of hydrogen, phenyl or 3-(2-oxopyrrolidin-l-yl) propyl; and R3 is hydrogen or alkyl of from 1-4 carbon atoms.

Synthesis and evaluation of antimycobacterial activity of new benzimidazole aminoesters

Abstract A total of 51 novel benzimidazoles were synthesized by a 4-step reaction starting from basic compound 4-fluoro-3-nitrobenzoic acid under relatively mild reaction conditions. The structure of the novel benzimidazoles was confirmed by mass spectra as well as 1H NMR spectroscopic data. Out of the 51 novel synthesized compounds, 42 of them were screened for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv strain using BacTiter-Glo Microbial Cell Viability (BTG) method. Results of activity screened using Alamar Blue method was also provided for comparison purposes. Two of the novel benzimidazoles synthesized showed moderately good activity with IC50 of less than 15 μM. Compound 5g, ethyl 2-(4-(trifluoromethyl)phenyl)-1-(2-morpholinoethyl)-1H-benzo[d]imidazole-5-carboxylate, was found to be the most active with IC50 of 11.52 μM.

Discovery of a potent and highly fluorescent sirtuin inhibitor

In search for potent sirtuin inhibitors, a series of diversified 1,2-disubstituted benzimidazole analogues were synthesized using a one-pot method. The most potent compound in the series (BZD9L1) was discovered to show high autofluorescence which can be utilized to predict its localization in cells. More importantly, BZD9L1 displayed strong antiproliferative effects against a panel of cancer cells tested. Molecular docking studies also help to explain the observed structure-activity relationship.

DNA intercalating RuII polypyridyl complexes as effective photosensitizers in photodynamic therapy

Six substitutionally inert [RuII(bipy)2dppz]2+ derivatives (bipy=2,2′-bipyridine, dppz = dipyrido[3,2-a:2′,3′-c]phenazine) bearing different functional groups on the dppz ligand [NH2 (1),OMe (2),OAc (3),OH (4),C