129034-38-4

Basic information

• Product Name: 2-Iodo-5-hydroxypyridine
• Synonyms: 5-Hydroxy-2-iodopyridine;2-Iodo-5-hydroxypyridine;6-Iodo-3-pyridinol;iodopyridin-3-ol;6-Iodopyridin-3-ol;REF DUPL: 2-Iodo-5-hydroxypyridine;3-Pyridinol, 6-iodo-
• CAS NO: 129034-38-4
• Molecular Formula: C₅H₄INO
• Molecular Weight: 221
• Product Categories: Heterocyclic Series;Heterocyclic Compounds;Pyridines;Heterocycles
• Mol File: 129034-38-4.mol

Chemical Properties

• Melting Point: 149-151 °C
• Boiling Point: 399.681 °C at 760 mmHg
• Flash Point: 195.52 °C
• Appearance: Off-white powder
• Density: 2.142 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.683
• Storage Temp.: 2-8°C(protect from light)
• Solubility: Acetone (Slightly), DMSO (Slightly)
• PKA: 8.79±0.10(Predicted)
• CAS DataBase Reference: 2-Iodo-5-hydroxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Iodo-5-hydroxypyridine(129034-38-4)
• EPA Substance Registry System: 2-Iodo-5-hydroxypyridine(129034-38-4)

Safety Data

• Hazardous Substances Data: 129034-38-4(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-Iodo-5-hydroxypyridine is used as a synthetic building block for the development of complex organic molecules and pharmaceuticals. Its unique chemical structure, featuring both an iodine atom and a hydroxyl group, allows for versatile reactivity and functional group manipulation in synthetic processes.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Iodo-5-hydroxypyridine is used as a key intermediate in the synthesis of various therapeutic agents. Its presence in the molecular structure can contribute to the desired biological activity and pharmacological properties of the final drug product.
Used in Chemical Research:
2-Iodo-5-hydroxypyridine is also employed in chemical research as a model compound to study the reactivity and properties of pyridine derivatives. This helps researchers gain insights into the behavior of similar compounds and develop new synthetic strategies or applications in various fields.

Synthesis Reference(s)

The Journal of Organic Chemistry, 62, p. 3008, 1997 DOI: 10.1021/jo970062g

InChI:InChI=1/C5H4INO/c6-5-2-1-4(8)3-7-5/h1-3,8H

Upstream product

• 109-00-2 3-HYDROXYPYRIDINE 
• 1198765-41-1 2-bromo-5-[(tert-butyldimethylsilyl)oxy]pyridine 
• 55717-45-8 6-bromo-pyridin-3-ol 

Downstream Products

• 163129-79-1 2-iodo-5-methoxypyridine 
• 1313619-61-2 C₅₂H₇₆N₂O₄ 
• 910649-56-8 5-hydroxy-N-(phenylmethyl)-2-pyridinecarboxamide 
• 910649-37-5 4-[(5-hydroxy-2-pyridinyl)sulfonyl]benzonitrile 
• 910649-36-4 4-[(5-hydroxy-2-pyridinyl)thio]benzonitrile 
• 55758-32-2 6-fluoropyridin-3-ol 
• 221549-96-8 (E)-p-nitrophenyl 3-(2-methoxy-6-pyridinyl)acrylate 
• 173088-62-5 (E)-methyl 3-(2-methoxy-6-pyridinyl)acrylate 

Relevant articles and documents

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