129050-23-3

Basic information

• Product Name: (2S, 2’S)-6-Fluoro-2-(2’-oxiranyl)chromane
• Synonyms: (2S, 2’S)-6-Fluoro-2-(2’-oxiranyl)chromane;(2S)-6-Fluoro-3,4-dihydro-2-[(2S)-2-oxiranyl]-2H-1-Benzopyran;2S)-2-((2S)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)oxirane
• CAS NO: 129050-23-3
• Molecular Formula: C₁₁H₁₁FO₂
• Molecular Weight: 194.2022432
• Product Categories: Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics, Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 129050-23-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 291.7°C at 760 mmHg
• Flash Point: 137.8°C
• Appearance: /
• Density: 1.299g/cm³
• Vapor Pressure: 0.00334mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: (2S, 2’S)-6-Fluoro-2-(2’-oxiranyl)chromane(CAS DataBase Reference)
• NIST Chemistry Reference: (2S, 2’S)-6-Fluoro-2-(2’-oxiranyl)chromane(129050-23-3)
• EPA Substance Registry System: (2S, 2’S)-6-Fluoro-2-(2’-oxiranyl)chromane(129050-23-3)

Safety Data

• Hazardous Substances Data: 129050-23-3(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Oil

Uses

(-)-Nebivolol intermediate.

InChI:InChI=1/C11H11FO2/c12-8-2-4-9-7(5-8)1-3-10(14-9)11-6-13-11/h2,4-5,10-11H,1,3,6H2/t10-,11?/m0/s1

Upstream product

• 793669-26-8 [1R*(R*)]-6-fluoro-3,4-dihydro-2-(oxiran-2-yl)-2H-chromene 
• 621-84-1 O-benzyl carbamate 
• 99199-90-3 6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran 
• 100-46-9 benzylamine 
• 1322623-11-9 1-(6-fluorochroman-2-yl)ethane-1,2-diol 
• 1219915-05-5 (S)-6-fluoro-2-(oxiran-2-yl)chroman 
• 1219915-03-3 (S)-2-chloro-1-((R)-6-fluoro-1-benzopyran-2-yl)-ethanol 
• 905454-58-2 (S,S)-(+)-α-[(p-toluenesulfonyloxy)methyl](6-fluoro-2-chromanyl)methanol 

Downstream Products

• 118457-16-2 nebivolol 
• 1199945-26-0 2-{benzyl-[2-(6-fluoro-chroman-2-yl)-2-hydroxy-ethyl]-amino}-1-(6-fluoro-chroman-2-yl)-ethanol 
• 152520-56-4 DL-nebivolol hydrochloride 

Relevant articles and documents

PROCESS FOR THE SYNTHESIS OF INTERMEDIATES OF NEBIVOLOL

The present invention relates to a novel process for the synthesis of the intermediate compounds constituted by chromanyl haloketones of formula III and 6-fluoro-2-(oxiran-2-yl) chromans of formula I. The intermediates thus obtained can be used for the sy

PROCESS FOR THE PREPARATION OF NEBIVOLOL

The present invention relates to a novel process for the synthesis of the Nebivolol product depicted in Scheme 1, comprised of a reduced number of high-yield steps, and characterized by the enzymatic resolution of the chroman ester precursor.

PROCESS FOR PREPARING NEBIVOLOL

The present invention relates to a process for preparing Nebivolol and, more particularly, to an improved process for synthesizing enantiomerically enriched 6-fluoro chroman alcohol or epoxide derivatives of formula, wherein R and X is defined in the description; as useful intermediates in the preparation of Nebivolol.