129053-52-7Relevant academic research and scientific papers
A stereoselective synthesis of (Z)-3-aryl and alkylmethylidene-1H- isoindolin-1-ones
Lamblin, Marc,Couture, Axel,Deniau, Eric,Grandclaudon, Pierre
, p. 1333 - 1338 (2007/10/03)
A series of Z-configured (hetero)aryl and alkylmethylideneisoindolin-1-ones has been efficiently prepared by treatment of N-methoxycarbonylisoindolin-1- ones with a base and reaction with selected aldehydes. The parent N-acylated isoindolin-1-ones have be
A New Alkaline Rearrangement of the Benzofuran Skeleton. One Step Transformation of 2-(2-Benzofuranyl)benzonitriles Into (Z)-Phenylmethyleneisoindolinones
Guillaumel, J.,Boccara, N.,Demerseman, P.,Royer, R.,Bideau, J. P.,et al.
, p. 605 - 614 (2007/10/02)
The alkaline hydrolysis of 2-(2-benzofuranyl)benzonitriles 2 by potassium hydroxide under reflux in ethanol stops at the corresponding amides 5.Using other solvents (ethylene glycol or methoxyethanol) at higher temperatures, one can obtain either the amides 5, the acids 1 or rearrangement products depending on the experimental conditions.The rearrangement products were identified as (Z)-phenylmethylenedihydroisoindolinones 6 resulting from opening of the furan ring.The structures of the compounds 6 were established by 1H nmr spectroscopy (nOe) and X-ray crystallography.
