1290541-27-3

Basic information

• Product Name: 3-ethynyl-3-Methyloxetane
• Synonyms: 3-ethynyl-3-Methyloxetane
• CAS NO: 1290541-27-3
• Molecular Formula: C6H8O
• Molecular Weight: 96.12712
• Mol File: 1290541-27-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-ethynyl-3-Methyloxetane(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ethynyl-3-Methyloxetane(1290541-27-3)
• EPA Substance Registry System: 3-ethynyl-3-Methyloxetane(1290541-27-3)

Safety Data

• Hazardous Substances Data: 1290541-27-3(Hazardous Substances Data)

Usage

General Description

3-Ethynyl-3-Methyloxetane is a complex organic compound that belongs to the class of organic compounds known as Oxetanes. These are compounds containing an oxetane moiety, a saturated three membered ring which bears an oxygen atom and three alkyl groups. 3-Ethynyl-3-methyloxetane specifically has two substituents on position 3 of the oxetane ring: an ethynyl group (consisting of two carbon atoms triple-bonded together) and a methyl group (a single carbon atom bonded to three hydrogen atoms). As a chemical, its use and properties can vary greatly depending on the context in which it is being utilized, notably in experimental scientific research, manufacturing or other professional settings. Its exact physical properties like molecular weight, boiling point, melting point, etc., will depend on detailed chemical analysis.

Upstream product

• 99419-31-5 3-methyloxetane-3-carboxaldehyde 
• 90965-06-3 dimethyl 1-(1-diazo-2-oxopropyl)phosphonate 
• 1335514-86-7 3-(2,2-dibromoethenyl)-3-methyloxetane 
• 3143-02-0 3-hydroxymethyl-3-methyloxethane 

Downstream Products

• 1215868-94-2 (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine 

Relevant articles and documents

ASK1 INHIBITING AGENTS

Provided are compounds of Formulas (I'), (I), (II') and (II), or pharmaceutically acceptable salts thereof, and methods for their use and production.

Inhibitors of β-site amyloid precursor protein cleaving enzyme (BACE1): Identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5′ H -spiro[chromeno[2,3- b ]pyridine-5,4′-oxazol]-2′-amine (AMG-8718)

We have previously shown that the aminooxazoline xanthene scaffold can generate potent and orally efficacious BACE1 inhibitors although certain of these compounds exhibited potential hERG liabilities. In this article, we describe 4-aza substitution on the xanthene core as a means to increase BACE1 potency while reducing hERG binding affinity. Further optimization of the P3 and P2′ side chains resulted in the identification of 42 (AMG-8718), a compound with a balanced profile of BACE1 potency, hERG binding affinity, and Pgp recognition. This compound produced robust and sustained reductions of CSF and brain Aβ levels in a rat pharmacodynamic model and exhibited significantly reduced potential for QTc elongation in a cardiovascular safety model.