129063-88-3

Upstream product

• 78782-17-9 4,4,5,5-tetramethyl-2-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-1,3,2-dioxaborolane 
• 57086-65-4 (E)-1-Iodo-2-methyl-1-hexene 
• 693-02-7 hex-1-yne 

Downstream Products

• 129063-99-6 (1R*,2R*)-2-Ethenyl-2-methyl-1-phenyl-1-hexanol 
• 129064-19-3 <4R*-(4α,5β)>-5-butyl-2,2,5-trimethyl-4-phenyl-1,3-dioxane 
• 129064-09-1 <4R*-(4α,5α)>-5-butyl-2,2,5-trimethyl-4-phenyl-1,3-dioxane 
• 129064-04-6 (1R*,3R*)-2-Hydroxymethyl-2-methyl-1-phenyl-hexanol 
• 129064-14-8 (1R*,3S*)-2-Hydroxymethyl-2-methyl-1-phenyl-hexanol 
• 129063-94-1 (1S*,2R*)-2-Ethenyl-2-methyl-1-phenyl-1-hexanol 

Relevant academic research and scientific papers

Diastereo- A nd Enantioselective Synthesis of Homoallylic Amines Bearing Quaternary Carbon Centers

A Cu-catalyzed method for the efficient enantio- A nd diastereoselective synthesis of chiral homoallylic amines bearing a quaternary carbon and an alkenylboron is disclosed. Transformations are promoted by a readily prepared (phosphoramidite)-Cu complex and involve bench-stable ?,?-disubstituted allyldiborons and benzyl imines; products are obtained in up to 82% yield, >20:1 dr, and >99:1 er. Reactions proceed via stereodefined boron-stabilized allylic Cu species formed by an enantioselective transmetalation. Utility of the 1-amino-3-alkenylboronate products is highlighted by a variety of synthetic transformations.