129076-93-3

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 142794-45-4 1-{(2R,3aS,9aR)-3-[(E)-Hydroxyimino]-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-1H-pyrimidine-2,4-dione 
• 84828-97-7 1-((6aR,8R,9aR)-2,2,4,4-tetraisopropyl-9-oxotetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione 
• 129076-88-6 1-{(2R,4S,5R)-4-Hydroxy-3-[(Z)-hydroxyimino]-5-hydroxymethyl-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

NOVEL TYPES OF CYCLONUCLEOSIDES

Reduction of 2'-deoxy-2'-hydroxyiminouridine derivatives led to a "first generation" hydroxylamine (2'-deoxy-2'-hydroxyaminouridine 8, mostly arabino configuration) which on treatment with aldehydes afforded the corresponding nitrones 9 which were reduced to "second generation" hydroxylamines 12.The modified nucleosides bearing a hydroxylamino group at the 2'-position, when of arabino configuration underwent conjugate addition onto the uracil ring leading to novel types of cyclonucleosides (3,5,10,13).