129083-25-6Relevant academic research and scientific papers
Photochemically induced radical alkenylation of C(sp3)-H bonds
Amaoka, Yuuki,Nagatomo, Masanori,Watanabe, Mizuki,Tao, Keisuke,Kamijo, Shin,Inoue, Masayuki
, p. 4339 - 4345 (2015/02/19)
The direct alkenylation of C(sp3)-H bonds was achieved by employing benzophenone and 1,2-bis(phenylsulfonyl)ethylene under photo-irradiation conditions. This simple metal-free reaction enables the substitution of heteroatom-substituted methine, methylene and aliphatic C(sp3)-H bonds by (E)-sulfonylalkene units in a highly chemoselective manner. The derived sulfonylalkenes were further converted in a single step to the prenyl derivatives via a second photo-induced radical substitution and to the pyrrole derivatives via cyclization and aromatization steps. The present protocol thus serves as an efficient method for the direct extension of carbon skeletons for the synthesis of structurally complex natural products and pharmaceuticals. This journal is
Facile synthesis of E-γ-hydroxy-α,β-unsaturated sulfones from aldehydes
Dominguez,Carretero
, p. 2487 - 2490 (2007/10/02)
Reaction of enolizable aldehydes with p-tolylsulfinylmethyl phenyl sulfone (1), in the presence of piperidine in acetonitrile at 0°C, gave selectively E-γ-hydroxy-α,β-unsaturated phenyl sulfones in good yields.
A practical route to (E)-γ-hydroxy-αβ-unsaturated phenyl sulfones
Dominguez, Esteban,Carretero, Juan Carlos
, p. 7197 - 7206 (2007/10/02)
Reaction of enolizable aldehydes with p-tolylsulfinylmethyl phenyl sulfone (1) in the presence of piperidine in acetonitrile gave selectively E-γ-hydroxy-αβ-unsaturated phenyl sulfones (2) in good yields. Reaction from enantiomerically pure sulfoxide 1 gave unsaturated sulfones 2 in moderate optical yields (ee= 10-50%).
