129095-40-5

Usage

Type

Nitrile derivative of allyloxyphenyl ketone

Physical Form

White to off-white crystalline powder

Melting Point

96-98°C

Solubility

Soluble in organic solvents such as ethanol, methanol, and acetone

Applications

Intermediate in pharmaceutical and agrochemical industries
Building block in the synthesis of other organic compounds
Research tool in organic chemistry
Reagent in the production of pharmaceutical ingredients

Upstream product

• 5443-37-8 ethyl 4-(n-prop-2'-enyloxy)benzoate 
• 75-05-8 acetonitrile 
• 120-47-8 Ethyl 4-hydroxybenzoate 

Downstream Products

• 129095-27-8 6-cyclohexyl-6,7-dihydro-4-(phenylmethyl)-2-(4-(2-propenyloxy)phenyl)-4H-pyrazolo<1,5-a>pyrrolo<3,4-d>pyrimidine-5,8-dione 
• 130681-00-4 6-cyclohexyl-6,7-dihydro-4-(phenylmethyl)-2-(4-hydroxyphenyl)-4H-pyrazolo<1,5-a>pyrrolo<3,4-d>pyrimidine-5,8-dione 
• 129117-16-4 6-cyclohexyl-6,7-dihydro-2-(4-(2-propenyloxy)phenyl)-4H-pyrazolo<1,5-a>pyrrolo<3,4-d>pyrimidine-5,8-dione 
• 951790-64-0 5-(4-(allyloxy)phenyl)-1-(2,4-chlorophenyl)-4-cyano-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide 
• 951790-65-1 5-(4-(allyloxy)phenyl)-1-(2-bromophenyl)-4-cyano-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide 
• 921590-81-0 1-(2,4-dichlorophenyl)-4-cyano-5-(4-hydroxyphenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide 
• 951790-66-2 1-(2-bromophenyl)-4-cyano-5-(4-hydroxyphenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide 
• 951790-61-7 5-(4-(allyloxy)phenyl)-1-(2,4-dichlorophenyl)-4-cyano-1H-pyrazole-3-carboxylic acid 
• 951790-62-8 5-(4-(allyloxy)phenyl)-1-(2-bromophenyl)-4-cyano-1H-pyrazole-3-carboxylic acid 
• 951790-58-2 ethyl 5-(4-(allyloxy)phenyl)-1-(2,4-dichlorophenyl)-4-cyano-1H-pyrazole-3-carboxylate 
• 951790-59-3 ethyl 5-(4-(allyloxy)phenyl)-1-(2-bromophenyl)-4-cyano-1H-pyrazole-3-carboxylate 
• 129095-41-6 5-(4-(2-propenyloxy)phenyl)-1H-pyrazol-3-amine 

Relevant academic research and scientific papers

Synthesis of 1-(2,4-dichlorophenyl)-4-cyano-5-(4-[11C] methoxyphenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide ([ 11C]JHU75528) and 1-(2-bromophenyl)-4-cyano-5-(4-[ 11C]methoxyphenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-c

Two novel ligands for cerebral cannabinoid receptor (CB1), 1-(2,4-dichlorophenyl)-4-cyano-5-(4-methoxyphenyl)-N-(piperidin-1-yl) -1H-pyrazole-3-carboxamide (JHU75528) and 1-(2-bromophenyl)-4-cyano-5-(4- methoxyphenyl)-N-(piperidin-1-yl)-1H-pyrazole-3-carb

Pyrazolo-pyrrolo-pyrimidine-diones

New pyrazolo-pyrrolo-pyrimidine-dione (PPPD) compounds of formula (I), STR1 where R1, R2, R3, R4 and m are as defined in the specification, e.g., 4-(benzoylmethyl)-6-cyclohexyl-6,7-dihydro-2-phenyl-4H-pyrazolo[1

Synthesis and Hypocholesterolemic Activity of 6,7-Dihydro-4H-pyrazolopyrrolopyrimidine-5,8-diones, Novel Inhibitors of AcylCoA:Cholesterol O-Acyltransferase

A novel series of 6,7-dihydro-4H-pyrazolopyrrolopyrimidine-5,8-dione inhibitors of the enzyme acylCoA:cholesterol O-acyltransferase is described.A number of these derivatives were found to be potent modulators of serum lipoprotein levels in