1291067-37-2

Upstream product

• 120-72-9 indole 
• 591-31-1 3-methoxy-benzaldehyde 
• 109-77-3 malononitrile 
• 2972-72-7 2-(3-methoxybenzylidene)malononitrile 

Relevant academic research and scientific papers

Electrochemical approach for synthesis of 3-substituted indole derivatives

An efficient and economical method was developed for synthesis of 3-substituted indole by using electrochemically induced condensation of various aldehyde, indole and malononitrile.

Water assisted and choline chloride-dimethylurea deep eutectic salts as catalyst towards the attractive reaction of indole, benzaldehyde, and malononitrile

The condensation of indole, benzaldehyde, and malononitrile was relatively rigorous compared with other Yonemitsu type reaction. We described a strategy using catalytic amount of choline chloride-dimethylurea deep eutectic salts as cheap and safe accelerator. We also found that introducing right amount of water in reaction system was crucial. This method tolerates variations in all three components to get desired 3-substituted indoles in satisfactory yields.

H5PW10V2O40@VOx/SBA-15-NH2 catalyst for the solventless synthesis of 3-substituted indoles

Functionalization of mesoporous SBA-15 frameworks by transition metal oxides offers a flexible route to fabricate new heterogeneous catalysts. Here, an inorganic-organic hybrid nanoporous catalyst H5PW10V2O40@VO

L - proline in catalytic multi-component generating 3 - substituted indole derivative use and method

The invention discloses application and a method of L-proline in catalyzing multiple components to generate a 3-substituted indole derivative. According to the method, under the catalysis of L-proline, a general formula 1, a general formula 2 and a compou

[TBA][Gly] ionic liquid promoted multi-component synthesis of 3-substituted indoles and indolyl-4H-chromenes

Tetrabutylammonium glycinate [TBA][Gly] ionic liquid was found to be an efficient recyclable and biodegradable organocatalyst for selective synthesis of 3-substituted indoles and indolyl-4H-chromenes. The reaction between substituted aliphatic/aromatic aldehydes, malononitrile, and indoles in the presence of [TBA][Gly] IL at 60 °C under solvent free conditions afforded 3-substituted indoles in excellent yields. Indolyl-4H-chromenes were achieved in excellent yields by replacing the benzaldehydes with salicylaldehyde under optimized reaction conditions.

L-Proline-catalyzed multicomponent synthesis of 3-indole derivatives

A green one-pot multicomponent reaction for the synthesis of 3-indole derivatives was developed via l-proline-catalyzed condensation between indoles, aldehydes, and malononitrile. The process was carried out in ethanol at room temperature, and the desired

Polyethylene glycol (PEG-200)-promoted sustainable one-pot three-component synthesis of 3-indole derivatives in water

A sustainable three-component reaction of indoles, aldehydes, and malononitrile in water promoted by polyethylene glycol (PEG-200) afforded 3-indole derivatives in good to excellent yields.

Synthesis of 3-indole derivatives by copper sulfonato Salen catalyzed three-component reactions in water

An efficient three-component reaction of indole, aldehyde, and malononitrile in water catalyzed by a copper(ii) sulfonato Salen complex afforded 3-indole derivatives in good to excellent yields up to 97%. The Royal Society of Chemistry.