1291097-50-1Relevant academic research and scientific papers
Organocatalyzed enantioselective Michael addition of 2-hydroxy-1,4- naphthoquinone to β,γ-unsaturated α-ketophosphonatesθ
Liu, Tao,Wang, Youming,Wu, Guiping,Song, Haibin,Zhou, Zhenghong,Tang, Chuchi
, p. 4119 - 4124 (2011)
By employing a cinchonine-based thiourea as catalyst, highly enantioselective Michael addition reactions of 2-hydroxy-1,4-naphthoquinone to β,γ-unsaturated α-ketophosphonates were realized. The reaction afforded the corresponding β-substituted carboxylates in excellent yields with high levels of enantioselectivities (94->99% ee) upon quenching the generated parent structures with DBU and MeOH as a second nucleophile.
