129121-69-3

Upstream product

• 121903-84-2 (4-Amino-butyl)-[2-(5-{2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-3-carbamoyl-propionylamino}-pentylcarbamoyl)-ethyl]-carbamic acid benzyl ester 
• 3392-05-0 Boc-Ala-O-N-hydroxysuccinimide 
• 134276-58-7 (4-Amino-butyl)-[2-(5-{2-[2-(2,4-bis-benzyloxy-phenyl)-acetylamino]-3-carbamoyl-propionylamino}-pentylcarbamoyl)-ethyl]-carbamic acid benzyl ester; compound with acetic acid 

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• 129624-95-9 N¹-(5-{3-[4-((S)-2-Amino-propionylamino)-butylamino]-propionylamino}-pentyl)-2-[2-(2,4-dihydroxy-phenyl)-acetylamino]-succinamide 

Relevant academic research and scientific papers

Total synthesis of clavamine, insecticidally active compound isolated from venom of Joro spider (Nephila clavata)

Clavamine, a new insecticidal toxin isolated from the venom of Joro spider (Nephila clavata) was totally synthesized in order to confirm the proposed structure. In clavamine, a fragment of glycylalanine is inserted in the structure of NSTX-3, a New Guinean spider toxin. The synthesis determined the chemical structure of clavamine unambiguously.

STRUCTURE-ACTIVITY RELATIONSHIP OF NSTX-3, SPIDER TOXIN OF NEPHILA MACULATA

In a study on structure-activity relationship of spider toxin NSTX-3 obtained from venom of Nephila maculata, nine analogs or fragments of natural toxin were synthesized.Among them, des-Arg-NSTX-3 was found to be the minimum structure for blocking the excitatory transmission in the crustacean neuromuscular synapse.A positive charge of the arginine part was concluded to play the most important role for exhibition of the activity.