129128-04-7

Basic information

• Product Name: Glutathionylcobalamin
• Synonyms: Glutathionylcobalamin
• CAS NO: 129128-04-7
• Molecular Formula: C72H104CoN16O20PS
• Molecular Weight: 1635.663321
• Mol File: 129128-04-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Glutathionylcobalamin(CAS DataBase Reference)
• NIST Chemistry Reference: Glutathionylcobalamin(129128-04-7)
• EPA Substance Registry System: Glutathionylcobalamin(129128-04-7)

Safety Data

• Hazardous Substances Data: 129128-04-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C62H90N13O14P.C10H17N3O6S.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19);/q;;+3/p-3

Upstream product

• 795216-66-9 hydroxocobalamin 
• 70-18-8 GLUTATHIONE 
• 20623-13-6 nitrocobalamin 

Relevant articles and documents

Mechanistic studies on the reaction of nitrocobalamin with glutathione: Kinetic evidence for formation of an aquacobalamin intermediate

The essential but also toxic gaseous signaling molecule nitric oxide is scavenged by the reduced vitamin B12 complex cob(II)alamin. The resulting complex, nitroxylcobalamin [NO--Cbl(III)], is rapidly oxidized to nitrocobalamin (NO2Cbl) in the presence of oxygen; however, it is unlikely that nitrocobalamin is itself stable in biological systems. Kinetic studies on the reaction between NO2Cbl and the important intracellular antioxidant, glutathione (GSH), are reported. In this study, a reaction pathway is proposed in which the β-axial ligand of NO2Cbl is first substituted by water to give aquacobalamin (H 2OCbl+), which then reacts further with GSH to form glutathionylcobalamin (GSCbl). Independent measurements of the four associated rate constants k1, k-1, k2, and k-2 support the proposed mechanism. These findings provide insight into the fundamental mechanism of ligand substitution reactions of cob(III)alamins with inorganic ligands at the β-axial site. Kinetic studies on the reaction of nitrocobalamin (NO2Cbl) with glutathione show that glutathionylcobalamin (GSCbl) is formed via an aquacobalamin (H 2OCbl+) intermediate. This reaction pathway is demonstrated by independently determining individual rate constants for each step.

NANOSTRUCTURES SUITABLE FOR DELIVERY OF AGENTS

Novel nanolattices comprising cross-linked or chelated polymers having a desired polydispersity index suitable for delivery of pharmaceutical agents and complexes comprising same are described. Methods of making the nanolattices and use of the nanolattices to deliver pharmaceutical agents for use in a range of diagnostic, prophylactic, therapeutic, nutritional and/or research applications are also described.