20623-13-6 Usage
Uses
Used in Pharmaceutical Industry:
Nitritocobalamin is used as a synthetic intermediate for the production of Hydroxocobalamin Acetate (H826800), a physiological analog of vitamin B12 where the CN group is replaced with OH. nitritocobalamin is essential for the synthesis of coenzymes that are vital for the proper functioning of the human body.
Used in Coordination Compounds:
Nitritocobalamin is utilized as a coordination compound, which are complexes that consist of a central metal atom or ion bonded to surrounding molecules or ions, known as ligands. These compounds have various applications in the fields of chemistry, biology, and materials science.
Used in Vitamin (Hematopoeitic) Applications:
As a form of vitamin B12, nitritocobalamin is used in the treatment of anemia and other hematopoietic disorders. It plays a crucial role in the production of red blood cells and the maintenance of a healthy nervous system.
Check Digit Verification of cas no
The CAS Registry Mumber 20623-13-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,6,2 and 3 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 20623-13:
(7*2)+(6*0)+(5*6)+(4*2)+(3*3)+(2*1)+(1*3)=66
66 % 10 = 6
So 20623-13-6 is a valid CAS Registry Number.
InChI:InChI=1/C62H90N13O14P.Co.HNO2/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;2-1-3/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;(H,2,3)/q;+3;/p-3
20623-13-6Relevant academic research and scientific papers
Mechanistic studies on the reaction of nitrocobalamin with glutathione: Kinetic evidence for formation of an aquacobalamin intermediate
Walker, David T.,Dassanayake, Rohan S.,Garcia, Kamille A.,Mukherjee, Riya,Brasch, Nicola E.
supporting information, p. 3049 - 3053 (2013/07/27)
The essential but also toxic gaseous signaling molecule nitric oxide is scavenged by the reduced vitamin B12 complex cob(II)alamin. The resulting complex, nitroxylcobalamin [NO--Cbl(III)], is rapidly oxidized to nitrocobalamin (NO2Cbl) in the presence of oxygen; however, it is unlikely that nitrocobalamin is itself stable in biological systems. Kinetic studies on the reaction between NO2Cbl and the important intracellular antioxidant, glutathione (GSH), are reported. In this study, a reaction pathway is proposed in which the β-axial ligand of NO2Cbl is first substituted by water to give aquacobalamin (H 2OCbl+), which then reacts further with GSH to form glutathionylcobalamin (GSCbl). Independent measurements of the four associated rate constants k1, k-1, k2, and k-2 support the proposed mechanism. These findings provide insight into the fundamental mechanism of ligand substitution reactions of cob(III)alamins with inorganic ligands at the β-axial site. Kinetic studies on the reaction of nitrocobalamin (NO2Cbl) with glutathione show that glutathionylcobalamin (GSCbl) is formed via an aquacobalamin (H 2OCbl+) intermediate. This reaction pathway is demonstrated by independently determining individual rate constants for each step.
