129138-51-8Relevant articles and documents
Total Synthesis of the Nonadjacently Linked Bis-tetrahydrofuran Acetogenin Bullatanocin (Squamostatin C)
Zhu, Lei,Mootoo, David R.
, p. 3154 - 3157 (2004)
The total synthesis of the nonadjacently linked bis-THF acetogenin bullatanocin (squamostatin C) is described. The synthetic strategy is a modular one based on three components, two mono-THF alkenes and a butenolide precursor, and the olefin cross-metathesis and Wittig olefination as the segment-coupling reactions. The synthesis confirms the structure of the natural product, and its convergent design makes it especially attractive for analogue synthesis.