129141-63-5

Upstream product

• 98510-20-4 myo-Inositol orthoformate 
• 1380085-21-1 C₂₂H₂₅N₃O₅ 
• 1380085-06-2 1,3-di-O-benzyl-2-azido-2-deoxy-4,6-O-methylidene-neo-inositol 
• 1380085-00-6 C₃₀H₃₁F₃O₉S 
• 1338649-69-6 1,3-O-methylidene-2-O-(4-methoxybenzyl)-4,6-di-O-benzyl-myo-inositol 
• 129213-04-3 (3aS,4S,4aR,7aR,8R,8aS)-8-Azido-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-ol 
• 129213-06-5 (3aS,4R,4aR,7aR,8R,8aS)-8-Azido-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-ol 
• 129213-03-2 2-azido-2-deoxy-myo-inositol 
• 129141-62-4 (3aS,4R,4aR,7aS,8S,8aR)-8-Methoxy-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-ylamine 
• 129141-62-4 (3aS,4R,4aR,7aS,8R,8aR)-8-Methoxy-2,2,6,6-tetramethyl-hexahydro-benzo[1,2-d;4,5-d']bis[1,3]dioxol-4-ylamine 
• 31077-12-0 Pentaacetyl 2-Azido-2-deoxy-myo-inosit 

Downstream Products

• 129141-64-6 1,3,4,6-tetra-O-acetyl-2-acetylamino-2-deoxy-5-O-methyl-neo-inositol 
• 129141-65-7 Acetic acid (2S,3S,4S,5S)-4-acetoxy-5-{2-acetoxy-4-[(E)-2-((1R,2S,3R,4S,5S,6R)-2,3,5,6-tetraacetoxy-4-methoxy-cyclohexylcarbamoyl)-propenyl]-phenoxy}-2-(2-methyl-[1,3]dioxolan-2-yl)-tetrahydro-furan-3-yl ester 

Relevant academic research and scientific papers

Synthesis of the aminocyclitol units of (-)-hygromycin A and methoxyhygromycin from myo-inositol

Concise and efficient syntheses of the aminocyclitol cores of hygromycin A (HMA) and methoxyhygromycin (MHM) have been achieved starting from readily available myo-inositol. Reductive cleavage of myo-inositol orthoformate to the corresponding 1,3-acetal, stereospecific introduction of the amino group via the azide, and resolution of a racemic cyclitol derivative as its diastereomeric mandelate esters are the key steps in the synthesis. Synthesis of the aminocyclitol core of hygromycin A involved chromatography in half of the total number of steps, and the aminocyclitol core of methoxyhygromycin involved only one chromatography.

Total Synthesis of Methoxyhygromycin and Its 5-Epimer

Methoxyhygromycin, an antibiotic having a unique structure among the aminocyclitol antibiotics, and its 5-epimer are first synthesized.This synthesis fully confirmed the proposed structure of the antibiotic and revealed that neo-configuration of cyclitol