129143-93-7Relevant academic research and scientific papers
Catalysed Oxygenation of Allylic Hydroperoxides Derived from Qinghao (Artemisinic) Acid. Conversion of Qinghao Acid into Dehydroqinghaosu (Artemisitene) and Qinghaosu (Artemisinin)
Haynes, Richard K.,Vonwiller, Simone C.
, p. 451 - 453 (1990)
Photo-oxygenation of qinghao acid and its dihydro analogue provides allylic hydroperoxides which are converted either indirectly via the corresponding esters, or directly into dehydroqinghaosu (artemisitene) and the antimalarial qinghaosu (artemisinin), by treatment with a catalitic amount of copper(II) trifluoromethanesulphonate with or without an iron(III) co-catalyst in dichloromethane-acetonitrile under oxygen.
