
Journal of the Chemical Society. Chemical communications p. 451 - 453 (1990)
Update date:2022-08-03
Topics:
Haynes, Richard K.
Vonwiller, Simone C.
Photo-oxygenation of qinghao acid and its dihydro analogue provides allylic hydroperoxides which are converted either indirectly via the corresponding esters, or directly into dehydroqinghaosu (artemisitene) and the antimalarial qinghaosu (artemisinin), by treatment with a catalitic amount of copper(II) trifluoromethanesulphonate with or without an iron(III) co-catalyst in dichloromethane-acetonitrile under oxygen.
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