129144-53-2

Upstream product

• 79-33-4 L-Lactic acid 
• 129144-52-1 pivalophenone dimethyl acetal 
• 938-16-9 2,2-dimethylpropiophenone 
• 80372-11-8 (S)-(-)-trimethylsilyl 2-<(trimethylsilyl)oxy>propanoate 

Downstream Products

• 141739-91-5 (2S,5R)-5-Bromo-2-tert-butyl-5-methyl-2-phenyl-[1,3]dioxolan-4-one 
• 141739-93-7 (2R,5R)-2-tert-Butyl-5-(1-hydroxy-1-methyl-propyl)-5-methyl-2-phenyl-[1,3]dioxolan-4-one 
• 141739-92-6 (2R,5R)-2-tert-Butyl-5-(1-hydroxy-1-methyl-ethyl)-5-methyl-2-phenyl-[1,3]dioxolan-4-one 

Relevant academic research and scientific papers

Diastereoselective synthesis and structural determination of 1,3-dioxolan-4-ones from lactic acid and carbonyl derivatives

New 1,3-dioxolan-4-ones were prepared by reacting lactic acid with the corresponding ketones.Depending on steric interactions and the cyclization method chosen, a good selectivity was achieved favoring cis or trans diastereomers.Relative stereochemistry and product conformation is discussed on the basis of NMR spectra.Key Words: dioxolanes / chirality transfer / lactic acid / relative stereochemistry

Chirality transfer from lactic acid selective synthesis of 2,2-disubstituted-1,3-dioxolan-4-ones from ketones and acetals

Diastereomeric 2,2-disubstituted-5-methyl-1,3-dioxolan-4-ones were prepared from lactic acid and ketones or their acetals with excellent control of stereochemistry under kinetic or thermodynamic reaction conditions.