129151-80-0Relevant academic research and scientific papers
Phase-transfer catalyzed glycolate conjugate addition
Andrus, Merritt B.,Ye, Zhifeng
, p. 534 - 537 (2008)
Cinchonine based phase-transfer catalysts were developed for enantioselective conjugate additions to electron deficient alkenes, including acylates, acrylonitrile, and chalcone. N-Trifulorobenzyl cinchoninium bromide 6 catalyst (20 mol %) in THF at -40 °C promoted the conjugate addition of arylketone glycolate 1 generating S-product 2 in good yields and selectivities. Catalyst, solvent, and base variations are presented along with conditions to convert the products to intermediates useful for multistep applications.
