Tetrahedron Letters p. 534 - 537 (2008)
Update date:2022-07-29
Topics: Catalyst Nucleophile Phase-transfer catalysis Conjugate addition Reactant glycolate
Andrus, Merritt B.
Ye, Zhifeng
Cinchonine based phase-transfer catalysts were developed for enantioselective conjugate additions to electron deficient alkenes, including acylates, acrylonitrile, and chalcone. N-Trifulorobenzyl cinchoninium bromide 6 catalyst (20 mol %) in THF at -40 °C promoted the conjugate addition of arylketone glycolate 1 generating S-product 2 in good yields and selectivities. Catalyst, solvent, and base variations are presented along with conditions to convert the products to intermediates useful for multistep applications.
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Doi:10.1021/jm1015022
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(1991)
