129151-98-0

Upstream product

• 129152-07-4 <2-(2-aminophenyl)-1-(4-methoxyphenyl)ethyl>-2-methylpropanedioic acid, dimethyl ester 
• 107967-05-5 [1-(4-Methoxyphenyl)-2-(2-nitrophenyl)ethyl]-propanedioic acid,dimethyl ester 
• 129151-97-9 <1-(4-methoxyphenyl)-2-(2-nitrophenyl)ethyl>-2-methylpropanedioic acid, dimethyl ester 
• 88-72-2 1-methyl-2-nitrobenzene 
• 7443-25-6 dimethyl 2-(4-methoxybenzylidene)malonate 

Downstream Products

• 119217-37-7 (3S,4S)-1-(2-Dimethylamino-ethyl)-4-(4-methoxy-phenyl)-3-methyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 
• 119217-37-7 (3R,4S)-1-(2-Dimethylamino-ethyl)-4-(4-methoxy-phenyl)-3-methyl-1,3,4,5-tetrahydro-benzo[b]azepin-2-one 
• 119217-58-2 (E) (cis)-1,3,4,5-Tetrahydro-4-(4-methoxyphenyl)-3-methyl-2H-1-benzazepin-2-one 
• 119217-36-6 cis-3-methyl-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one, monohydrochloride 
• 129151-99-1 cis-1,3,4,5-tetrahydro-3-methyl-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 
• 119217-58-2 trans-1,3,4,5-tetrahydro-3-methyl-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one 

Relevant academic research and scientific papers

Benzazepinone Calcium Channel Blockers. 3. Synthesis and Structure-Activity Studies of 3-Alkylbenzazepinones

As part of a program aimed at identifying novel analogues of diltiazem, we developed several synthetic routes for 3-alkylbenzazepinones, both in racemic and nonracemic form.Structure-activity relationship studies in this series have led to identification

Benzazepinone calcium channel blockers. 4. Structure-activity overview and intracellular binding site

We have synthesized a series of benzazepinones (2) in order to determine the structure-activity relationships (SAR) for calcium channel blockers related to diltiazem. A prerequisite for calcium channel blocking activity in vitro and in vivo is the presenc