129159-22-4

Upstream product

• 80336-64-7 2-bromo-1-(4'-isobutyl-phenyl)-propan-1-one 
• 59771-24-3 4-isobutylpropiophenone 
• 65961-36-6 p-isobutyl-α-methoxypropiophenone 

Downstream Products

• 169295-48-1 2-acetoxy-1-(4-isobutylphenyl)-1-propanone 
• 129159-24-6 1-fluoroethyl 4-isobutylphenyl ketone 
• 151647-67-5 (R)-2-hydroxy-1-(4-isobutylphenyl)-1-propanone 

Relevant academic research and scientific papers

Resolution of Secondary α-Ketoalcohols Catalyzed by Lipase and Inversioon of Stereochemistry

Several α-ketoalcohols of synthetic value were resolved using lipase as a catalyst.Lipoprotein lipase (LPL) provided the best rate of hydrolysis and kinetic differentiation.One of these optically pure α-ketoalcohol was converted to (S)-ibuprofen in good optical purity.The stereospecific inversion of (R)-alcohol to (S)-alcohol is described.Key Words Enzymatic resolution; α-Ketoalcohol; (S)-Ibuprofen

Enzymes in Organic Synthesis: Lipase Catalyzed Resolution of Secondary α-Ketoalcohols

Resolution of several α-ketoalcohols of synthetic value using lipase as a catalyst is described.