129177-18-0Relevant academic research and scientific papers
1,2,4-Triazolo[4,3-c]quinazolines: a bioisosterism-guided approach towards the development of novel PCAF inhibitors with potential anticancer activity
El-Shershaby, Mohamed H.,Ghiaty, Adel,Bayoumi, Ashraf H.,Ahmed, Hany E. A.,El-Zoghbi, Mona S.,El-Adl, Khaled,Abulkhair, Hamada S.
, p. 11136 - 11152 (2021)
Targeting PCAF with small inhibitor molecules has emerged as a potential therapeutic strategy for the treatment of cancer. Recently, L-45 was identified as a potent triazolophthalazine inhibitor of the PCAF bromodomain. Here, we report the bioisosteric modification of the triazolophthalazine ring system of L-45 to its bioisosteric triazoloquinazoline while maintaining other essential structural fragments for effective binding with the binding site of PCAF. Consequently, a set of sixteen triazoloquinazoline derivatives were designed, synthesized, and investigated for their anticancer activity against four human cancer cell lines. Five derivatives demonstrated comparable cytotoxic activity with that of doxorubicin as a reference anticancer drug. Among them, compound23showed the most potent activity with IC50values of 6.12, 4.08, 7.17, and 6.42 μM against HePG2, MCF-7, PC3, and HCT-116, respectively. Also, compound21exhibited comparable cytotoxic effects with that of doxorubicin against the selected cancer cell lines with IC50values in the range of 7.41-9.58 μM. Molecular docking and pharmacokinetic studies were additionally performed to rationalize the binding affinities of the newly designed triazoloquinazolines toward the active site of histone acetyltransferase PCAF and to evaluate the druggability of new compounds. The results of these studies suggested that PCAF binding could be the mechanism of action of these derivatives.
Compound and application thereof
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Paragraph 0182-0184; 0189-0190, (2021/10/27)
The invention relates to a compound and application thereof. At the same time, the 1 electron injection and migration performance of the molecule can be improved, and the electron injection and the migration efficiency in the device can be effectively improved when the compound of the invention is used Ar as an electron transport layer material, particularly when the compound is used as an electron transport layer material. Thus, it is ensured that the device obtains high light emission efficiency. An excellent effect of a low starting voltage.
Compound and application thereof
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Paragraph 0113-01115; 0118-0119, (2021/09/21)
The compound has the structure shown in the formula (1), X is CH or N, and L is selected from a single bond. The substituted or unsubstituted C6 - C60 arylene group, the substituted or unsubstituted C3 - C60 heteroarylene group, the Ar is selected from one of a substituted or unsubstituted C6 - C60 aryl group, a substituted or unsubstituted C3 - C60 heteroaryl group. When the compound provided by the invention is applied OLED devices, the efficiency of the device can be effectively improved, the driving voltage is reduced, and the compound is a good-performance electronic transmission material.
Compound and application thereof
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Paragraph 0118; 0120; 0123-0124, (2021/10/05)
The compound has the structure shown in the formula (I) or the formula (II) and R. 1 Selected from H. Deuterium, halogen, cyano, nitro, alkenyl, alkynyl, carboxy, C1 - C20 chain alkyl, C3 - C20 cycloalkyl, C1 - C20 alkoxy, substituted or unsubstituted C6 - C60 aryl, substituted or unsubstituted C3 - C60 heteroaryl, and the heteroatom in the heteroaryl is selected from O or S. L Is one selected from a single bond, a substituted or unsubstituted C6 - C60 arylene group, a substituted or unsubstituted C3 - C60 heteroarylene group. R Is one selected from H, deuterium, halogen, cyano, nitro, alkenyl, alkynyl, carboxy, C1 - C20 chain alkyl, C3 - C20 cycloalkyl, C1 - C20 alkoxy, substituted or unsubstituted C6 - C60 aryl, substituted or unsubstituted C3 - C60 heteroaryl. Ar Is a substituted or unsubstituted C6 - C60 aryl group, a substituted or unsubstituted C3 - C60 heteroaryl group. When the compound is applied OLED devices, the device efficiency can be effectively improved, the driving voltage is reduced, and the compound is a good-performance electronic transmission material.
Compound and application thereof
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Paragraph 0109-0111; 0114-0115, (2021/10/27)
The invention relates to a compound and application thereof. At the same time, the 1 electron injection and migration performance of the molecule can be 5 improved 6 - so that the electron injection and the migration efficiency in the device can Ar be effectively improved when the compound of the present invention is used as an electron transport layer material. Thus, it is ensured that the device obtains high light emission efficiency. An excellent effect of a low starting voltage.
Compound and organic electroluminescent device
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, (2019/01/08)
The invention provides a compound, which is shown as a following general formula (I) or (II) in the specification, wherein, X is selected from CR 4 or N; R 1 to R 4 are respectively and independentlyselected from hydrogen, C1-C10 alkyl groups, substituted or unsubstituted C5 -C60 aryl or heteroaryl groups, the substituent of aryl or heteroaryl groups is selected from deuterium, fluorine, methyl group, methoxy group, cyano group, phenyl group, biphenyl group, naphthyl group, phenanthryl group, and substituted or unsubstituted anthracyl group, the substituent of the anthracyl group is selectedfrom the group consisting of phenyl, biphenyl, terphenyl, naphthyl, and phenanthryl; and a dotted line and Cy in the general formula (II) represent a five- or six-membered aromatic or heteroaromatic ring fused to a pyrimidine ring. The compound can be used in an organic electroluminescent device. The invention also provides an organic electroluminescent device comprising the above compound.
