129177-66-8Relevant academic research and scientific papers
(Z)-Stereoselective Wittig Olefination of 2-Oxygenated Indol-3(2H)-ones
Kawasaki, Tomomi,Nonaka, Yoshinori,Ohtsuka, Hiroaki,Sato, Hiroshi,Sakamoto, Masanori
, p. 1101 - 1106 (1990)
The Wittig reaction of 1-acetyl-2-methoxy- (1) and 1-acetyl-2-hydroxyindol-3(2H)-one (2) with stabilized and semistabilized ylides gave predominantly 3-alkylidenedihydroindoles (4), (7), and (13) with (Z)-stereochemistry.When the Wittig reaction was carried out under more drastic conditions, the Wittig products (4) and (7) isomerized to afford 3-alkylindoles (5) and the indol-2-one (8), respectivily.These isomerizations are also described.
