129185-32-6Relevant academic research and scientific papers
Efficient chemical synthesis of a pyrimidine (6-4) pyrimidone photoproduct analog and its properties
Satou, Kousuke,Komatsu, Yasuo,Torizawa, Takuya,Kato, Koichi,Shimada, Ichio,Nikaido, Osamu,Ohtsuka, Eiko
, p. 2175 - 2179 (2007/10/03)
We synthesized an analog of a pyrimidine (6-4) pyrimidone photoproduct with a formacetal linkage instead of the phosphodiester in the (6-4) photoproduct, and investigated the interaction between a monoclonal antibody specific to the natural (6-4) photopro
An efficient approach to the synthesis of thymidine derivatives containing phosphate-isosteric methylene acetal linkages
Veeneman,Van Der Marel,Van Den Elst,Van Boom
, p. 1547 - 1562 (2007/12/18)
Iodonium ion promoted condensation of properly protected 3′-O-methylthiomethyl or 3′-O-(4-penten-1-oxymethyl)-thymidine with 3′-O-methoxyacetyl-thymidine, was explored. A judicious choice of the iodoinium source and protecting groups led to an efficient preparation of thymidine dimers having internucleosidic-3′5′)-methylene bonds. The latter procedure was utilized towards the synthesis, in solution and on a solid support, of DNA-fragments containing one or more T-CII2-T dimers. Further, 5′-O-methylthiomethyl-3′-O-methoxyacetyl-N 3-benzoyl-thymidine proved to be a suitable donor for the introduction of 5′-O-methylene acetal-linkage s between 2,3,4,6-tetra-Obenzyl-D-glucose, benzyl N-benzyloxycarbonyl-L-serine and dibenzyl phosphate.
Deoxyoligonucleotide Analogs based on Formacetal Linkages
Matteucci, Mark
, p. 2385 - 2388 (2007/10/02)
This report describes the synthesis of a trimer of thymidine bearing formacetal linkages, its incorporation into a longer deoxyoligonuleotide and characterization of the hybridization properties with a complementary RNA sequence.
