129197-02-0

Basic information

• Product Name: 3-methyl-6-(diphenylhydroxymethyl)pyridine
• Synonyms: 3-methyl-6-(diphenylhydroxymethyl)pyridine
• CAS NO: 129197-02-0
• Molecular Weight: 275.35
• Mol File: 129197-02-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-methyl-6-(diphenylhydroxymethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-6-(diphenylhydroxymethyl)pyridine(129197-02-0)
• EPA Substance Registry System: 3-methyl-6-(diphenylhydroxymethyl)pyridine(129197-02-0)

Safety Data

• Hazardous Substances Data: 129197-02-0(Hazardous Substances Data)

Upstream product

• 1003-73-2 3-picoline-N-oxide 
• 119-61-9 benzophenone 
• 129197-01-9 3-methyl-6-(diphenylhydroxymethyl)pyridine N-oxide 
• 3510-66-5 2-Bromo-5-methylpyridine 
• 108-99-6 3-Methylpyridine 
• 6457-37-0 (3-methylpyridine)BF₃ 

Relevant articles and documents

Transition-Metal Free Chemoselective Hydroxylation and Hydroxylation-Deuteration of Heterobenzylic Methylenes

We developed an approach for direct selective hydroxylation of heterobenzylic methylenes to secondary alcohols avoiding overoxidation to ketones by using a KOBu-t/DMSO/air system. Most reactions could reach completion in several minutes to give hydroxylated products in 41-76% yields. Using DMSO-d6, this protocol resulted in difunctionalization of heterobenzylic methylenes to afford α-deuterated secondary alcohols (>93% incorporation). By employing this method, active pharmaceutical ingredients carbinoxamine and doxylamine were synthesized in two steps in moderate yields.

Complex-induced proximity effect in the regioselective lithiation of pyridine derivatives

The regioselective ring lithiation of BF3-complexed 3-picoline (1a), 3,4-lutidine (1b), and 3,5-lutidine (1c) was studied. The dilithiation of 1a, 1b, and 1c was also investigated to experimentally explore the relative preference of the sites on the substituted pyridine ring for lithiation. The role of the complex-induced proximity effect (CIPE) for inducing lithiation in these moieties was investigated using both experimental and computational studies.