129201-92-9Relevant articles and documents
Synthesis of the core structure of the fungal metabolite benesudon: Use of oxidative decarboxylation
Clive, Derrick L. J.,Minaruzzaman,Yang, Haikang
, p. 5581 - 5583 (2005)
(Chemical Equation Presented) The core structure (5) of the fungal metabolite benesudon (1) was synthesized, the key step being oxidative decarboxylation of acid 17.
Asymmetric Nazarov Cyclizations Catalyzed by Chiral-at-Metal Complexes
Mietke, Thomas,Cruchter, Thomas,Larionov, Vladimir A.,Faber, Tabea,Harms, Klaus,Meggers, Eric
, p. 2093 - 2100 (2018/04/19)
The application of Lewis acidic chiral-at-metal complexes of iridium(III) and rhodium(III) as catalysts for the asymmetric polarized Nazarov cyclization of dihydropyran- and indole-functionalized α-unsaturated β-ketoesters is reported (overall 24 examples). For both substrate classes, catalyst loadings of 2 mol% were found to be sufficient for achieving high yields and high stereoselectivities. The cyclized dihydropyran products were isolated in 85–98% yield, with 89%–>99% ee, and trans/cis ratios of 15:1–50:1 (9 examples). The cyclized indole products were typically isolated in more than 70% yield and in up to 93% yield, typically with more than 90% ee and in up to 97% ee, and trans/cis ratios of 12:1–28:1 (15 examples). (Figure presented.).
The naturally occurring ketene acetal benesudon: Total synthesis and assignment of relative and absolute stereochemistry
Clive, Derrick L. J.,Minaruzzaman,Yang, Haikang
, p. 6743 - 6752 (2008/12/23)
(Chemical Equation Presented) The densely functionalized ketene acetal benesudon, which is a bioactive fungal metabolite, was synthesized from D-glucose by a route involving radical cyclization to form the five-membered ring, and oxidative decarboxylation
