129215-08-3

Upstream product

• 129261-96-7 dimethyl (1R,2R)-3,3-bis(methylthio)cyclobutane-1,2-dicarboxylate 
• 124282-19-5 methyl (1R,2R)-3,3-bis(methylthio)-2-((2-oxo-1,3-oxazolidin-3-yl)carbonyl)cyclobutanecarboxylate 
• 124282-17-3 (1R,2R)-(3,3-bis(methylthio)-2-(hydroxymethyl)cyclobutyl)methanol 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Relevant academic research and scientific papers

Asymmetric [2 + 2] cycloaddition reaction catalyzed by a chiral titanium reagent

In the presence of certain Lewis acids, alkenes containing an alkylthio group (for example, ketene dithioacetals, alkenyl sulfides, alkynyl sulfides, and allenyl sulfides) react with electron deficient olefins to give the corresponding cyclobutane, cyclobutene, or methylene cyclobutane derivatives. By employing a chiral titanium catalyst generated in situ from dichlorodiisopropoxytitanium and a tartrate-derived chiral diol, the [2 + 2] cycloaddition reaction proceeds with high enantioselectivity.

Novel cyclobutane derivative and process for producing same

This invention relates to cyclobutane derivatives represented by the following general formula (IV): wherein B represents a nucleic acid base and R4 represents hydrogen atom or a protecting group, which is expectedly useful as an antiviral agen