129227-27-6

Basic information

• Product Name: 4-FLUOROBENZENECARBALDEHYDE N-(3-OXO-3,4-DIHYDRO-2-QUINOXALINYL)HYDRAZONE
• Synonyms: 4-FLUOROBENZENECARBALDEHYDE N-(3-OXO-3,4-DIHYDRO-2-QUINOXALINYL)HYDRAZONE
• CAS NO: 129227-27-6
• Molecular Formula: C₁₅H₁₁FN₄O
• Molecular Weight: 282.27
• Mol File: 129227-27-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-FLUOROBENZENECARBALDEHYDE N-(3-OXO-3,4-DIHYDRO-2-QUINOXALINYL)HYDRAZONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUOROBENZENECARBALDEHYDE N-(3-OXO-3,4-DIHYDRO-2-QUINOXALINYL)HYDRAZONE(129227-27-6)
• EPA Substance Registry System: 4-FLUOROBENZENECARBALDEHYDE N-(3-OXO-3,4-DIHYDRO-2-QUINOXALINYL)HYDRAZONE(129227-27-6)

Safety Data

• Hazardous Substances Data: 129227-27-6(Hazardous Substances Data)

Upstream product

• 31595-63-8 3-hydrazineylidene-3,4-dihydroquinoxalin-2(1H)-one 
• 459-57-4 4-fluorobenzaldehyde 
• 95-54-5 1,2-diamino-benzene 
• 15804-19-0 quinoxaline-2,3-dione 

Downstream Products

• 129227-31-2 1-(4-fluorophenyl)-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one 

Relevant articles and documents

Design, synthesis and photoinduced DNA cleavage studies of [1,2,4]-triazolo[4,3-a]quinoxalin-4(5H)-ones

An expedient and eco-friendly synthesis of 1-aryl/heteroaryl-[1,2,4]-triazolo[4,3-a]quinoxalin-4(5H)-ones (4) has been accomplished via iodobenzene diacetate mediated oxidative intramolecular cyclization of 3-(2-(aryl/heteroarylidene)hydrazinyl)-quinoxalin-2(1H)-ones (3). Ten synthesized compounds 3 and 4 (10–40 μg) on irradiation with UV light at λmax 312 nm could lead to cleavage of supercoiled pMaxGFP DNA (Form I) into the relaxed DNA (Form II) without any additive. Further, DNA cleaving ability of triazoles was quantitatively evaluated and was found to be dependent on its structure, concentration, and strictly on photoirradiation time. Mechanistic investigations using several additives as potential inhibitors/activator revealed that the DNA photocleavage reaction involves Type-I pathway leading to formation of superoxide anion radicals (O2 ? [rad]) as the major reactive oxygen species responsible for photocleavage process.