1292283-48-7

Basic information

• Product Name: C₂₅H₃₈N₈O₆S₃
• Synonyms: C₂₅H₃₈N₈O₆S₃
• CAS NO: 1292283-48-7
• Molecular Weight: 642.825
• Mol File: 1292283-48-7.mol

Chemical Properties

• CAS DataBase Reference: C₂₅H₃₈N₈O₆S₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₃₈N₈O₆S₃(1292283-48-7)
• EPA Substance Registry System: C₂₅H₃₈N₈O₆S₃(1292283-48-7)

Safety Data

• Hazardous Substances Data: 1292283-48-7(Hazardous Substances Data)

Upstream product

• 890015-39-1 N,N-bis(2-thioethyl)glycine disulfide hydrochloride 
• 35737-10-1 N-Fmoc-β-alanine 
• 71989-14-5 Fmoc-(tBu)Asp-OH 
• 187618-60-6 Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine 

Relevant articles and documents

Synthesis, in vitro screening and in vivo evaluation of cyclic RGD analogs cyclized through oxorhenium and oxotechnetium coordination

A library of RGD tripeptide analogs cyclized through oxorhenium coordination by an NS2/S chelation motif was synthesized. Screening towards integrins αVβ3, αIIbβ3 and αVβ5 led to the identification of 6 oxorhenium complexes that bind to integrin αVβ3 in the submicromolar range. In vivo evaluation of five of the corresponding oxotechnetium complexes using nude mice bearing a U87MG human tumor xenograft showed a significant and specific accumulation of radioactivity inside the tumor. The best results in vivo were obtained with complexes Tc-16 and Tc-50 that displayed a higher tumor accumulation and a lower distribution in other tissues relative to a reference cyclopentapeptide tracer.