1292297-03-0Relevant academic research and scientific papers
Synthesis and biological evaluation of 4 arylcoumarin analogues as tubulin-targeting antitumor agents
Mutai, Peggoty,Breuzard, Gilles,Pagano, Alessandra,Allegro, Diane,Peyrot, Vincent,Chibale, Kelly
, p. 1652 - 1665 (2017/02/26)
The synthesis of twenty-six 4-arylcoumarin analogues of combretastatin A-4 (CA-4) led to the identification of two new compounds (25 and 26) with strong cytotoxic activity. Both compounds had a high cytotoxic effect on a CA-4-resistant colon adenocarcinoma cell line (HT29D4). The compounds affected cell cycle progression characterized by a mitotic block. The activity of these compounds against microtubules both in vitro and in cells was examined and both compounds were found to potently inhibit in vitro microtubule formation via a sub-stoichiometric mode like CA-4. By immunofluorescence, it was observed that both compounds induced strong microtubule network disruption. Our results provide a strong experimental basis to develop new potent anti-tubulin molecules targeting CA-4-resistant cancer cells.
Synthesis of hydrophilic and lipophilic 4-arylcoumarin phosphates
Selikhov,Malysheva,Nyuchev,Sitnikov,Sharonova,Shavyrin,Combes,Fedorova
, p. 2003 - 2009 (2012/09/07)
Novel hydrophilic and lipophilic prodrugs, sodium 4-arylcoumarin dialkylphosphates and 4-arylcoumarin dioleyl phosphates, were synthesized by phosphorylation of 4-arylcoumarins with dialkylphosphites.
Synthesis and biological evaluation of 4-arylcoumarin analogues of combretastatins. Part 2
Combes, Sébastien,Barbier, Pascale,Douillard, Soazig,McLeer-Florin, Anne,Bourgarel-Rey, Véronique,Pierson, Jean-Thomas,Fedorov, Alexey Yu.,Finet, Jean-Pierre,Boutonnat, Jean,Peyrot, Vincent
, p. 3153 - 3162 (2011/06/27)
Figure Presented. A series of A-ring variously methoxylated 4-(3-hydroxy-4-methoxyphenyl)coumarins related to combretastatin A-4 was prepared by cross-coupling reactions. Cytotoxicity studies indicated a potent activity against HBL100 cell line. Substitut
