1292323-11-5

Basic information

• Product Name: methyl 2-(2'-dimethoxyphosphoryl-1'-methyl-2'-phenylcyclopropyl-1'-methylimino)-3-phenylpropanoate
• Synonyms: methyl 2-(2'-dimethoxyphosphoryl-1'-methyl-2'-phenylcyclopropyl-1'-methylimino)-3-phenylpropanoate
• CAS NO: 1292323-11-5
• Molecular Weight: 429.453
• Mol File: 1292323-11-5.mol

Chemical Properties

• CAS DataBase Reference: methyl 2-(2'-dimethoxyphosphoryl-1'-methyl-2'-phenylcyclopropyl-1'-methylimino)-3-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(2'-dimethoxyphosphoryl-1'-methyl-2'-phenylcyclopropyl-1'-methylimino)-3-phenylpropanoate(1292323-11-5)
• EPA Substance Registry System: methyl 2-(2'-dimethoxyphosphoryl-1'-methyl-2'-phenylcyclopropyl-1'-methylimino)-3-phenylpropanoate(1292323-11-5)

Safety Data

• Hazardous Substances Data: 1292323-11-5(Hazardous Substances Data)

Upstream product

• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 

Downstream Products

• 1292323-13-7 (2S)-methyl 2-(2'-dimethoxyphosphoryl-1'-methyl-2'-phenylcyclopropyl-1'-methylamino)-3-phenylpropanoate 
• 1292323-13-7 (2S)-methyl 2-(2'-dimethoxyphosphoryl-1'-methyl-2'-phenylcyclopropyl-1'-methylamino)-3-phenylpropanoate 

Relevant articles and documents

(2-Formyl-1-phenylcyclopropyl)phosphonates as building blocks for (2-aminomethyl-cyclopropyl)phosphonates

A diastereomeric mixture of dimethyl (2-formyl-2-methyl-1- phenylcyclopropyl)phosphonate ((Z)-6, (E)-6) was obtained by thermally induced cyclopropanation of α-methylacrolein with α-diazobenzylphosphonate 5. Application of proline or proline-derived organocatalysts accelerated the reaction, but had a minor effect on the Z/E ratio of 6. By reaction with benzylamine or methyl esters of glycine, (S)-alanine, and (S)-phenylalanine, the Z/E-mixture of 6 was converted into cyclopropylaldimines, which after reduction gave the corresponding N-substituted (2-aminomethyl-cyclopropyl)phosphonates.