129245-40-5

Upstream product

• 129312-19-2 Ethyl (1R,2S,4S,5S)-2,4-dihydroxy-5-methyl-2-(2-trimethylsilyl-3-furyl)cyclohexanecarboxylate 
• 74-88-4 methyl iodide 
• 129313-41-3 Ethyl (1R,2S,4S,5S)-2-hydroxy-4-<(2S)-2-hydroxy-2-phenylacetoxy>-5-methyl-2-(2-trimethylsilyl-3-furyl)cyclohexanecarboxylate 

Downstream Products

• 129245-48-3 Methyl (6R,2Z,4E,8E)-6,8-dimethyl-2-<(1S,2R,4S,5S)-1-hydroxy-5-methoxy-4-methyl-2-(2-trimethylsilylethoxycarbonyl)cyclohexan-1-yl>-10-<(2R,4S,6R,8R,9S)-4-tert-butyldimethylsilyloxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-deca-2,4,8-trie... 
• 129245-49-4 (1R,2S,4S,5S)-2-<(6R,2Z,4E,8E)-6,8-Dimethyl-10-<(2R,4S,6R,8R,9S)-4-hydroxy-9-methyl-8-isopropyl-1,7-dioxaspiro<5.5>undecan-2-yl>-1-methoxy-1-oxadeca-2,4,8-trien-2-yl>-2-hydroxy-4-methoxy-5-methylcyclohexanecarboxylic acid 
• 129245-42-7 2-Trimethylsilylethyl (1R,2S,4S,5S)-2-hydroxy-4-methoxy-5-methyl-2-(2-trimethylsilyl-3-furyl)cyclohexanecarboxylate 
• 188472-63-1 2-Trimethylsilylethyl (1R,2S,4S,5S)-2-hydroxy-2-(5-hydroxy-2-oxo-1-oxacyclopent-3-en-3-yl)-4-methoxy-5-methylcyclohexanecarboxylate 
• 129245-41-6 (1R,2S,4S,5S)-2-Hydroxy-4-methoxy-5-methyl-2-(2-trimethylsilyl-3-furyl)cyclohexanecarboxylic acid 

Relevant academic research and scientific papers

Total synthesis of milbemycin E: Resolution of the C(1)-C(10) fragment and final assembly

The racemic hydroxycyclohexanone (±)-7, prepared by the Robinson addition of the keto ester 5 to 3-methylbut-3-enone 6, has been reduced stereoselectively to give the racemic cyclohexanediol (±)-8. This has been resolved by fractional crystallisation of t

A Total Synthesis of Milbemycin E

Milbemycin E (1) and 3,4-dihydromilbemycin E (34) have been synthesized, the C(1)-C(10) fragment being prepared using a stereoselective Robinson annelation.