129247-46-7

Upstream product

• 111269-40-0 3-(p-tolyl)-1,1,1-trifluoropropane-2,3-dione 3-dimethylhydrazone 
• 133593-18-7 2-(N',N'-Dimethyl-hydrazino)-3,3,3-trifluoro-2-hydroxy-1-p-tolyl-propan-1-one 
• 111269-60-4 3,3,3-trifluoro-1-(p-tolyl)propane-1,2-dione 
• 133593-25-6 3-(p-tolyl)-1,1,1-trifluoropropane-2,3-dione 2-dimethylhydrazone 

Relevant academic research and scientific papers

Convenient and selective synthesis of 4-trifluoromethylimidazoles

Thermally induced cyclization of 3-aryl-1, 1, 1-trifluoropropane-2, 3-dione 2-dimethylhydrazones (5) which can be readily prepared from corresponding arenecarbaldehydes afforded selectively the title compounds (3) in high yields without formation of the r

4- and 5-Trifluoromethylimidazoles. Novel Cyclization of Trifluoroacetylated Aldehyde Dimethylhydrazones

Thermally induced cyclization reaction of trifluoroacetylated arylaldehyde dimethylhydrazones 1 in refluxing toluene afforded 1-methyl-4-aryl-5-trifluoromethylimidazoles 2 in good yields.In contrast thermal cyclization of 1 in the presence of silica gel gave regioisomeric 1-methyl-4-trifluoromethyl-5-aryl-imidazoles 5 as major products.These reactions could be extended to the synthesis of related several 1,4,5-trisubstituted imidazoles.