129247-50-3Relevant academic research and scientific papers
Thermal reaction of 5-aryl-6-trifluoromethyl-3,6-dihydro-2H-[1,3,4]oxadiazines accessing 5-trifluoromethylimidazols
Kamitori, Yasuhiro,Sekiyama, Tomoko,Okada, Etsuji
, p. 351 - 356 (2007)
Thermal reaction of 5-aryl-6-trifluoromethyl-3,6-dihydro-2H-[1,3,4]oxadiazines (2) readily obtainable from 3-aryl-3-dimethylhydrazono-1,1,1-trifluoro-2-propanones (1) afforded 4-aryl-l-methyl-5-trifluoromethyl-imidazoles (3) in moderate to good yields. Mechanism for this thermal transformation reaction is also discussed.
4- and 5-Trifluoromethylimidazoles. Novel Cyclization of Trifluoroacetylated Aldehyde Dimethylhydrazones
Kamitori, Yasuhiro,Hojo, Masaru,Masuda, Ryoichi,Ohara, Seiji,Kawasaki, Kazuyoshi,et al.
, p. 487 - 495 (2007/10/02)
Thermally induced cyclization reaction of trifluoroacetylated arylaldehyde dimethylhydrazones 1 in refluxing toluene afforded 1-methyl-4-aryl-5-trifluoromethylimidazoles 2 in good yields.In contrast thermal cyclization of 1 in the presence of silica gel gave regioisomeric 1-methyl-4-trifluoromethyl-5-aryl-imidazoles 5 as major products.These reactions could be extended to the synthesis of related several 1,4,5-trisubstituted imidazoles.
Convenient and selective synthesis of 4-trifluoromethylimidazoles
Kamitori, Yasuhiro,Hojo, Masaru,Masuda, Ryoichi,Kawamura, Yoshihiko,Fang, Xie
, p. 2103 - 2106 (2007/10/02)
Thermally induced cyclization of 3-aryl-1, 1, 1-trifluoropropane-2, 3-dione 2-dimethylhydrazones (5) which can be readily prepared from corresponding arenecarbaldehydes afforded selectively the title compounds (3) in high yields without formation of the r
