129247-64-9Relevant academic research and scientific papers
Tritylation of alcohols under mild conditions without using silver salts
Shahsavari, Shahien,Chen, Jinsen,Wigstrom, Travis,Gooding, James,Gauronskas, Alexander,Fang, Shiyue
, p. 3877 - 3880 (2016/08/02)
Secondary alcohols were conveniently tritylated under mild conditions within a short running time with tritylium trifluoroacetate generated in situ from trityl alcohols and trifluoroacetic anhydride. No expensive silver salts were needed for the reactions. Four secondary alcohols were tritylated with both mono- and dimethoxy trityl alcohols giving good to excellent isolated yields. The reaction was also tested on four nucleoside derivatives that have primary alcohols. Satisfactory results were also obtained.
4,4'-Dimethoxytrityl and 4-Monomethoxytrityl Tetrafluoroborate: Convenient Reagents for the Protection of Primary Alcohols Including Sugars
Bleasdale, Christine,Ellwood, Simon B.,Golding, Bernard T.
, p. 803 - 805 (2007/10/02)
In a non-donor solvent (e.g. acetonitrile) and in the presence of 2,6-di-t-butyl-4-methylpyridine, the readily prepared 4-methoxytrityl tetrafluoroborate (3) and 4,4'-dimethoxytrityl tetrafluoroborate (2) are highly effective reagents for the methoxytritylation and dimethoxytritylation, respectively, of primary alcohols including sugars.
