129247-66-1Relevant academic research and scientific papers
Copper(II)nitrate catalyzed regioselective protection of primary alcohols with 4,4′-dimethoxytrityl and 2,7-dimethyl-9-phenyl xanthen-9-yl groups in nucleosides and carbohydrates
Penjarla, Srishylam,Prasad, S. Rajendra,Reddy, Dhande Sudhakar,Banerjee, Shyamapada,Penta, Santhosh,Sanghvi, Yogesh S.
, p. 232 - 247 (2018/05/14)
Regioselective protection of primary hydroxyl group in nucleoside and carbohydrate analogs was accomplished using dimethoxytrityl alcohol (DMTr-OH) or dimethylpixyl alcohol (DMPx-OH) in presence of copper(II)nitrate as a Lewis acid catalyst. Excellent selectivity was observed for the protection of primary hydroxyl group over secondary while glycosidic bond remain unaffected. Utility of this methodology was further exemplified via DMTr- and DMPx-protection of alipahtic acyclic and cyclic diols.
An efficient and selective method for the preparation of triphenylmethyl ethers of alcohols and nucleosides
Zekri, Negar,Alamdari, Reza Fareghi
experimental part, p. 563 - 568 (2010/08/05)
A very simple and efficient method is described for the protection of alcohols and nucleosides with benzyl monomethoxytrityl and benzyl dimethoxytrityl ethers in the presence of diethylazodicarboxylate and a catalytic amount of ceric triflate. High selectivity was observed for the tritylation of 5'-OH function of nucleosides.
A solvent free and selective method for preparation of triphenylmethyl ethers of alcohols and nucleosides
Zekri, Negar,Alamdari, Reza Fareghi,Khalafi-Nezhad, Ali
experimental part, p. 299 - 304 (2012/04/23)
A very simple and efficient method is described for protection of alcohols and nucleosides with trityl(triphenylmethyl), mono and dimethoxytrityl chlorides in the presence of triethylamine under microwave irradiation. High selectivity was observed for tritylation of 5'-OH function of nucleosides.
4,4'-Dimethoxytrityl and 4-Monomethoxytrityl Tetrafluoroborate: Convenient Reagents for the Protection of Primary Alcohols Including Sugars
Bleasdale, Christine,Ellwood, Simon B.,Golding, Bernard T.
, p. 803 - 805 (2007/10/02)
In a non-donor solvent (e.g. acetonitrile) and in the presence of 2,6-di-t-butyl-4-methylpyridine, the readily prepared 4-methoxytrityl tetrafluoroborate (3) and 4,4'-dimethoxytrityl tetrafluoroborate (2) are highly effective reagents for the methoxytritylation and dimethoxytritylation, respectively, of primary alcohols including sugars.
